10094-58-3

• 常用中文名：水苏糖
• 常用英文名：STACHYOSE TETRAHYDRATE
• CAS号：10094-58-3
• 分子式：C₂₄H₅₀O₂₅
• 分子量：738.639
• 相关类别： 生物化工 糖类化合物 寡糖
• 发布时间：2018-05-07 08:00:00
• 更新时间：2024-01-07 11:27:25
• Stachyose是一种益生元,是rafnose低聚糖家族中的非还原性四糖,具有很少的副作用。
• 1．水苏糖可以有效防止并缓解婴幼儿便秘及腹泻，抑制肠道疾病。
  2．水苏糖可以全面增强婴幼儿的免疫能力，提高婴幼儿的机体抗病力。
  3. 水苏糖具有清肠道，排毒排铅的效果。
  4. 水苏糖在可以置换金属离子，从而促进钙等矿物质吸收。  
  　　人体摄入水苏糖后，由于消化道内缺乏α-D-半乳糖苷酶，水苏糖不经消化吸收可直接到达大肠内为双歧杆菌所利用，快速增殖双歧杆菌，使其在消化道内形成优势地位。
  　　双歧杆菌等有益菌代谢产生大量短链脂肪酸，降低肠道pH值，改善人体维生素代谢，刺激肠道产生免疫细胞，提高人体的免疫机能。促进胃肠蠕动防止便秘，控制肠炎，腹痛;并产生抗菌物质Bifidin及游离胆汁酸，使消化道内环境趋于良性发展。对腐生菌的生长有很强的抑制作用。
  1、生物屏障：水苏糖能迅速增殖肠道有益菌，使菌群能黏附于人体肠道内，形成一层厚厚的菌群膜，抵御致病菌，有效的阻止肠毒素的侵害。试验发现水苏糖对有害菌有较强的抑杀作用，降低肠道内胺和吲哚含量，降低如亚硝酸镁等致癌物质的活性；——防抗疾病复发  
  2、化学屏障：有益菌在水苏糖的激活下会产生大量的短链脂肪酸，可降低肠道PH和EH值，阻止有害菌的生长，并促进肠道蠕动，加速致病菌及毒素的排泄；清除宿便，从而防治便秘。——清肠毒，除宿便，肠胃更安康  
  3、免疫屏障：水苏糖自身可分解出甘露三糖、蜜二糖等免疫功能因子，这些功能因子能促使产生人体内分泌量最大的免疫球蛋白(IGA)，能中和病毒、毒素及致病菌等生物活性抗原，具有广泛的保护作用。——自身免疫，世界上最好的医生 
  水苏糖 - 水苏糖的应用范围1、可添加在液体食品中，如乳酸饮料、醋饮料、啤酒等饮料中，开发出新型功能型食品，且添加量小，效果显著，不会破坏原有食品的风味。

名称

• 中文名: 水苏四糖,四水
• 英文名: stachyose
• 中文别名: 水苏糖
• 英文别名: b-D-Fructofuranosyl a-D-galactopyranosyl-(1->6)-a-D-galactopyranosyl-(1->6)-a-D-glucopyranoside tetrahydrate; EINECS 207-427-3; STACHYOSE TETRAHYDRATE; MFCD00071593; (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxyméthyl)tétrahydro-2-furanyl]oxy}-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}méthyl)tétrahydro-2H-pyran-2-yl]oxy}méthyl)tétrahydro-2H-pyran-3,4,5-triol tétrahydrate; stachyose; α-D-Glucopyranoside, β-D-fructofuranosyl O-α-D-galactopyranosyl-(1->6)-O-α-D-galactopyranosyl-(1->6)-, hydrate (1:4); (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydro-2-furanyl]oxy}-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-3,4,5-triol tetrahydrate; β-D-Fructofuranosyl α-D-galactopyranosyl-(1->6)-α-D-galactopyranosyl-(1->6)-α-D-glucopyranoside tetrahydrate; (2R,3R,4S,5S,6R)-2-{[(2S,3S,4S,5R)-3,4-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydro-2-furanyl]oxy}-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-({[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-3,4,5-trioltetrahydrat; α-D-Galactopyranosyl-(1->6)-α-D-galactopyranosyl-(1->6)-α-D-glucopyranoside de β-D-fructofuranosyle tétrahydrate; β-D-Fructofuranosyl-α-D-galactopyranosyl-(1->6)-α-D-galactopyranosyl-(1->6)-α-D-glucopyranosidetetrahydrat

物化性质

• 沸点: 1044.2ºC at 760 mmHg
• 熔点: 95-105 °C
• 分子式: C₂₄H₅₀O₂₅
• 分子量: 738.639
• 闪点: 585.3ºC
• 精确质量: 738.264099
• PSA: 384.75000
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 0mmHg at 25°C
• 折射率: 133 ° (C=5, H2O)
• 储存条件: 室温
• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：738.264117 Da

  8、标称质量：738 Da

  9、平均质量：738.6388 Da

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-8

  2、 氢键供体数量：14

  3、 氢键受体数量：21

  4、 可旋转化学键数量：11

  5、 拓扑分子极性表面积（TPSA）：348

  6、 重原子数量：45

  7、 表面电荷：3

  8、 复杂度：933

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：19

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：细微结晶。无还原性。

  2. 密度（g/mL,20℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：101-105

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：133 ° (C=5, H2O)

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水。

生物活性

• 描述: Stachyose是一种益生元,是rafnose低聚糖家族中的非还原性四糖,具有很少的副作用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 体外研究: 水苏糖通过诱导LAB产生更多的α-半乳糖苷酶来水解水苏糖,从而高度促进乳酸菌(LAB)的增殖[2]。
• 体内研究: 水苏糖可以通过抑制大豆染料木黄酮的肠道降解和首过代谢来改善染料木黄酮的生物利用度[1]。
• 动物实验: 小鼠[1]每组雄性昆明小鼠（n = 8）通过灌胃给予生理盐水，水苏糖（250 mg / kg体重），染料木黄酮（100 mg / kg体重）和水苏糖（50,250和500）。 mg / kg bw）与染料木黄酮（100 mg / kg体重）一起连续4周，然后收集他们的尿液，粪便，血液，肠道和肝脏[1]。
• 参考文献:

  [1]. Lu Y, et al. Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice. Food Nutr Res. 2017 Aug 30;61(1):1369343.

  [2]. Pan Q, et al. The Proliferation Mechanism of Lactobacillus plantarum RB1 Stimulated by Stachyose. Curr Microbiol. 2017 Jun;74(6):732-738.

MSDS

Name: Stachyose Tetrahydrate 98.5% Material Safety Data Sheet Synonym: None Known CAS: 10094-58-3 Section 1 - Chemical Product MSDS Name:Stachyose Tetrahydrate 98.5% Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 10094-58-3 Stachyose Tetrahydrate 98.5% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 10094-58-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white to off-white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 110 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C24H42O21.4H2O Molecular Weight: 738.64 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 10094-58-3 unlisted. LD50/LC50: Not available. Carcinogenicity: Stachyose Tetrahydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 10094-58-3: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 10094-58-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 10094-58-3 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): S24/25
• WGK德国: 3
• 海关编码: 1702900090

海关

海关编码	1702900090