103548-82-9

• 常用中文名：石杉碱甲B
• 常用英文名：Huperzine B
• CAS号：103548-82-9
• 分子式：C₁₆H₂₀N₂O
• 分子量：256.343
• 相关类别： 生物化工 天然产物
• 发布时间：2018-06-19 17:50:04
• 更新时间：2024-01-06 09:46:03
• Huperzine B 是从 Huperzia serrata 中分离出的石蒜生物碱和高度选择性的乙酰胆碱酯酶 (AChE) 抑制剂。Huperzine B 可以用于改善阿尔茨海默氏病。

名称

• 中文名: 石杉碱乙
• 英文名: Huperzine B
• 中文别名: 石山碱乙; 石杉碱甲B
• 英文别名: HuperzineB; (1R,9R,10R)-16-Methyl-6,14-diazatetracyclo[7.5.3.0.0]heptadeca-2(7),3,16-trien-5-one; 1H-5,10b-[1]Propeno-1,7-phenanthrolin-8(7H)-one, 2,3,4,4a,5,6-hexahydro-12-methyl-, (4aR,5R,10bR)-

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 533.5±50.0 °C at 760 mmHg
• 分子式: C₁₆H₂₀N₂O
• 分子量: 256.343
• 闪点: 216.4±30.3 °C
• 精确质量: 256.157562
• PSA: 44.89000
• LogP: 1.98
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.624
• 储存条件: 室温

生物活性

• 描述: Huperzine B 是从 Huperzia serrata 中分离出的石蒜生物碱和高度选择性的乙酰胆碱酯酶 (AChE) 抑制剂。Huperzine B 可以用于改善阿尔茨海默氏病。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点:

  AChE[1]

• 参考文献:

  [1]. Zhang HY, et al. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett. 2000 Sep 29;292(1):41-4.

  [2]. He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg Med Chem. 2007 Feb 1;15(3):1394-408.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : OL2780000 CHEMICAL NAME : Lycodin-1(18H)-one, 8,15-didehydro- CAS REGISTRY NUMBER : 103548-82-9 LAST UPDATED : 198912 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C16-H20-N2-O MOLECULAR WEIGHT : 256.38 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 43841 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25125 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987

合成路线

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文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

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文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

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文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

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文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1391435-96-3 ~% 103548-82-9 107965-41-3

文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

1391436-01-3 ~% 103548-82-9 107965-41-3

文献：Journal of Organic Chemistry, , vol. 79, # 1 p. 240 - 250

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