1021950-26-4

• 常用中文名：酪氨酸激酶抑制剂
• 常用英文名：Tyrosine kinase inhibitor
• CAS号：1021950-26-4
• 分子式：C₃₁H₃₁FN₆O₅
• 分子量：586.61300
• 相关类别： 信号通路 蛋白酪氨酸激酶 c-Met的/HGFR
• 发布时间：2018-05-16 08:00:00
• 更新时间：2024-01-03 17:57:53
• 本产品为酪氨酸激酶抑制剂。

名称

• 中文名: N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]苯基]-N’-(4-氟苯基)-1,1-环丙烷二甲酰胺
• 英文名: 1-N'-(4-fluorophenyl)-1-N-[4-[[2-(2-morpholin-4-ylethylcarbamoyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]cyclopropane-1,1-dicarboxamide
• 英文别名: N-(4-fluorophenyl)-N'-(4-{[2-({[2-(4-morpholinyl)ethyl]amino}carbonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)-1,1-cyclopropanedicarboxamide; cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)quinolin-4-yloxy]phenyl}amide (4-fluorophenyl)amide; XL184-Supplied by Selleck Chemicals; S1119_Selleck; CS-0524; Tyrosine kinase inhibitor

物化性质

• 分子式: C₃₁H₃₁FN₆O₅
• 分子量: 586.61300
• 精确质量: 586.23400
• PSA: 137.68000
• LogP: 4.38850
• 储存条件: 2-8℃

生物活性

• 描述: 本产品为酪氨酸激酶抑制剂。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR
  研究领域 >> 癌症
• 参考文献:

  [1]. Inoue T, et al. Two cases of gastrointestinal perforation after radiotherapy in patients receiving tyrosine kinase inhibitor for advanced renal cell carcinoma. World J Surg Oncol. 2012 Aug 20;10(1):167.

  [2]. Bowen JM, et al. Development of a rat model of oral small molecule receptor tyrosine kinase inhibitor-induced diarrhea. Cancer Biol Ther. 2012 Nov 1;13(13).

  [3]. Sun FK, et al. Multi-targeted tyrosine kinase inhibitor sunitinib: a novel strategy for sporadic malignant pheochromocytoma. Chin Med J (Engl). 2012 Jun;125(12):2231-4.

  [4]. Thamm DH. Tyrosine kinase inhibitor special issue. Vet Comp Oncol. 2012 Sep;10(3):161-2. doi: 10.1111/j.1476-5829.2012.00339.x.

  [5]. Eriksson A, et al. The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia. Blood Cancer J. 2012 Aug 3;2:e81. doi: 10.1038/bcj.2012.28.