512-16-3

• 常用中文名：环丁酸醇
• 常用英文名：Cyclobutyrol
• CAS号：512-16-3
• 分子式：C₁₀H₁₈O₃
• 分子量：186.24800
• 相关类别： 研究领域 内分泌
• 发布时间：2018-09-24 18:50:24
• 更新时间：2024-01-10 16:18:40
• 环丁醇是一种有效的利胆剂。环丁醇还抑制胆汁脂质分泌。环丁醇诱导利胆与胆汁酸无关。CB和胆汁酸不竞争肝胆转运机制【1】

名称

• 中文名: 环丁酸醇
• 英文名: cyclobutyrol
• 英文别名: Cyclobutyrol; 2-(1-Hydroxy-cyclohexyl)-buttersaeure; Cyclobutyrolum; Ciclobutirol; Hebucol; 2-(1-hydroxy-cyclohexyl)-butyric acid; cyclobutyral; 2-(1-hydroxycyclohexyl)butanoic acid

物化性质

• 密度: 1.128g/cm3
• 沸点: 334.1ºC at 760mmHg
• 分子式: C₁₀H₁₈O₃
• 分子量: 186.24800
• 闪点: 170.1ºC
• 精确质量: 186.12600
• PSA: 57.53000
• LogP: 1.79240
• 折射率: 1.508
• 储存条件: 2-8°C

生物活性

• 描述: 环丁醇是一种有效的利胆剂。环丁醇还抑制胆汁脂质分泌。环丁醇诱导利胆与胆汁酸无关。CB和胆汁酸不竞争肝胆转运机制【1】
• 相关类别:
  研究领域 >> 内分泌
• 参考文献:

  [1]. Monte MJ, et al. Choleretic mechanism and effects of cyclobutyrol in the rat: dose-response relationship. Biomed Biochim Acta. 1990; 49(1):83-90.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GU6555200 CHEMICAL NAME : Cyclohexaneacetic acid, alpha-ethyl-1-hydroxy- CAS REGISTRY NUMBER : 512-16-3 BEILSTEIN REFERENCE NO. : 2209058 LAST UPDATED : 199701 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C10-H18-O3 MOLECULAR WEIGHT : 186.28 WISWESSER LINE NOTATION : L6TJ AY2&VQ AQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4820 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3230 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1760 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1920 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,313,1982

安全

• 海关编码: 2918199090

海关

海关编码	2918199090
中文概述	HS: 2918199090. 其他含醇基但不含其他含氧基羧酸（包括其酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%