26308-28-1

• 常用中文名：利帕西泮
• 常用英文名：Ripazepam
• CAS号：26308-28-1
• 分子式：C₁₅H₁₆N₄O
• 分子量：268.31400
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-09-09 19:24:01
• 更新时间：2024-01-11 14:43:06
• 利帕西泮(Cl-683)是一种潜在的抗焦虑剂。利帕西泮也是一种吡唑啉二氮平酮衍生物,具有抗焦虑作用[1]。

名称

• 中文名: 利帕西泮
• 英文名: 1-ethyl-3-methyl-8-phenyl-4,6-dihydropyrazolo[4,3-e][1,4]diazepin-5-one
• 英文别名: 1-ethyl-3-methyl-8-phenyl-4,6-dihydro-1H-pyrazolo[4,3-e][1,4]diazepin-5-one; Ripazepamum [INN-Latin]; RIPAZEPAM; 1-Ethyl-1,4,5,6-tetrahydro-3-methyl-8-phenylpyrazolo(4,3-e)(1,4)diazepin-5-on; CI-683; Cl-683; Pyrazapon; Ripazepam [USAN:INN]

物化性质

• 密度: 1.28g/cm3
• 沸点: 466.6ºC at 760 mmHg
• 分子式: C₁₅H₁₆N₄O
• 分子量: 268.31400
• 闪点: 236ºC
• 精确质量: 268.13200
• PSA: 59.28000
• LogP: 1.57450
• 蒸汽压: 6.97E-09mmHg at 25°C
• 折射率: 1.664

生物活性

• 描述: 利帕西泮(Cl-683)是一种潜在的抗焦虑剂。利帕西泮也是一种吡唑啉二氮平酮衍生物,具有抗焦虑作用[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UR0100000 CHEMICAL NAME : Pyrazolo(4,3-e)(1,4)diazepin-5(1H)-one, 4,6-dihydro-1-ethyl-3-methyl-8-phenyl- CAS REGISTRY NUMBER : 26308-28-1 LAST UPDATED : 199703 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C15-H16-N4-O MOLECULAR WEIGHT : 268.35 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 81900 mg/kg/78W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,178,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 66,157,1996

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%