466-24-0

• 常用中文名：苯甲酰乌头原碱
• 常用英文名：benzoylaconine
• CAS号：466-24-0
• 分子式：C₃₂H₄₅NO₁₀
• 分子量：603.700
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-03-31 08:00:00
• 更新时间：2024-01-02 23:08:43
• Benzoylaconine(Isaconitine; Pikraconitin)是中药附子生物碱。

名称

• 中文名: 苯甲酰乌头原碱
• 英文名: Benzoylaconine
• 英文别名: Pikraconitin; Picraconitine; enzoylaconitine; Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 14-benzoate, (1α,3α,6α,14α,15α,16β)-; 8-O-deacetylaconitine; Isaconitine; 14-O-Benzoylaconine; benzoylaconine; Benzoylaconitine; (1α,3α,6α,14α,15α,16β)-20-Ethyl-3,8,13,15-tetrahydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl benzoate; Aconine 14-benzoate

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 711.4±60.0 °C at 760 mmHg
• 熔点: 130°C
• 分子式: C₃₂H₄₅NO₁₀
• 分子量: 603.700
• 闪点: 384.0±32.9 °C
• 精确质量: 603.304321
• PSA: 147.38000
• LogP: 0.90
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.631

生物活性

• 描述: Benzoylaconine(Isaconitine; Pikraconitin)是中药附子生物碱。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 其他
• 参考文献:

  [1]. Liu XX, et al. Determination of alkaloids in Radix Aconiti Lateralis Preparata by RP-ion-pair HPLC. Yao Xue Xue Bao. 2006 Apr;41(4):365-9.

  [2]. Borcsa B, et al. Diterpene alkaloids from the roots of Aconitum moldavicum and assessment of Nav1.2 sodium channel activity of aconitum alkaloids. Planta Med. 2014 Feb;80(2-3):231-6.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TJ7849250 CHEMICAL NAME : Picraconitine CAS REGISTRY NUMBER : 466-24-0 BEILSTEIN REFERENCE NO. : 0073066 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C32-H45-N-O10 MOLECULAR WEIGHT : 603.78 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 10100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 19,641,1984 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 5,324,1955

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