Dofequidar富马酸盐

• 常用名: Dofequidar富马酸盐
• 英文名: Dofequidar (fumarate)
• CAS号: 153653-30-6
• 分子量: 597.658
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₄H₃₅N₃O₇
• 熔点: N/A
• 闪点: N/A

Dofequidar富马酸盐用途

Dofequidar 延胡索酸盐(MS-209 延胡索酸盐)是口服活性的喹啉化合物,能抑制 ABCB1/P-gp,ABCC1/MDR-相关蛋白1。

Dofequidar富马酸盐名称

• 中文名: Dofequidar富马酸盐
• 英文名: Dofequidar fumarate

Dofequidar富马酸盐生物活性

• 描述: Dofequidar 延胡索酸盐(MS-209 延胡索酸盐)是口服活性的喹啉化合物,能抑制 ABCB1/P-gp,ABCC1/MDR-相关蛋白1。
• 相关类别:
  信号通路 >> 跨膜转运 >> P-糖蛋白
  研究领域 >> 癌症
• 参考文献:

  [1]. Nakanishi O, et al. Potentiation of the antitumor activity by a novel quinoline compound, MS-209, in multidrug-resistant solid tumor cell lines. Oncol Res. 1997;9(2):61-9.

  [2]. Naito M, et al. MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin Cancer Res. 2002 Feb;8(2):582-8.

  [3]. Nokihara H, et al. A new quinoline derivative MS-209 reverses multidrug resistance and inhibits multiorgan metastases by P-glycoprotein-expressing human small cell lung cancer cells. Jpn J Cancer Res. 2001 Jul;92(7):785-92.

  [4]. Katayama R, et al. Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci. 2009 Nov;100(11):2060-8.

Dofequidar富马酸盐物理化学性质

• 分子式: C₃₄H₃₅N₃O₇
• 分子量: 597.658
• 精确质量: 597.247498
• 储存条件: 2-8℃

Dofequidar富马酸盐英文别名

• 1-{4-[2-Hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl}-2,2-diphenylethanone (2E)-2-butenedioate (1:1)
• Ethanone, 1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-, (2E)-2-butenedioate (1:1) (salt)
• MFCD00925095
• Dofequidar (fumarate)