硫酸茚地那韦

• 常用名: 硫酸茚地那韦
• 英文名: Indinavir Sulfate
• CAS号: 157810-81-6
• 分子量: 711.868
• 密度: N/A
• 沸点: 877.9ºC at 760 mmHg
• 分子式: C₃₆H₄₉N₅O₈S
• 熔点: 150-153ºC
• 闪点: 484.7ºC

硫酸茚地那韦用途

Indinavir(MK-639; L735524)硫酸盐是HIV蛋白酶抑制剂,具有很好的口服生物相容性。

硫酸茚地那韦名称

• 中文名: 硫酸茚地那韦
• 英文名: Indinavir sulfate
• 中文别名: 茚地那非硫酸盐 | (1(1S,2R),5(S))-2,3,5-三脱氧-N-(2,3-二氢-2-羟基-1H-茚-1-基)-5-[2-[[(1,1-二甲基乙基)氨基]羰基]-4-(3-吡啶甲基)-1-哌嗪基]-2-(苯甲基)-D-赤式-戊酰胺硫酸盐

硫酸茚地那韦生物活性

• 描述: Indinavir(MK-639; L735524)硫酸盐是HIV蛋白酶抑制剂,具有很好的口服生物相容性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HIV蛋白酶
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Stein, D.S., et al., A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS, 1996. 10(5): p. 485-92.

  [2]. Liu, F., et al., Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol, 2005. 354(4): p. 789-800.

硫酸茚地那韦物理化学性质

• 沸点: 877.9ºC at 760 mmHg
• 熔点: 150-153ºC
• 分子式: C₃₆H₄₉N₅O₈S
• 分子量: 711.868
• 闪点: 484.7ºC
• 精确质量: 711.330200
• PSA: 201.01000
• LogP: 3.95250
• 外观性状: 白色粉末
• 蒸汽压: 5.56E-33mmHg at 25°C
• 储存条件: -20°C Freezer
• 水溶解性: Freely soluble in water, soluble in methanol, practically insoluble in heptane.

硫酸茚地那韦安全信息

• 安全声明 (欧洲): S36/37
• 海关编码: 2933990090

硫酸茚地那韦海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

硫酸茚地那韦英文别名

• MK-639,Crixivan
• Indinivar sulphate
• Indinavir Sulfate
• INDINAVIR SULPHATE
• Indinavir (sulfate)
• indinavirsulfate(subjecttopatentfree)
• (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (salt)
• (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (salt) (non-preferred name)
• (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-indén-1-yl]amino}-5-oxopentyl]-N-(1,1-diméthyléthyl)-4-(pyridin-3-ylméthyl)pipérazine-2-carboxamide sulfate (salt)
• Crixivan
• MK-639
• INDIGOWOADROOTEXTRACT
• IDV
• (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide sulfate (1:1) (non-preferred name)
• (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-(2-methyl-2-propanyl)-4-(3-pyridinylmethyl)-2-piperazinecarboxamide sulfate (1:1) (non-preferred name)
• (2S)-1-[(2S,4R)-4-Benzyl-2-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino}-5-oxopentyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazin-2-carboxamidsulfat(salt)