a2e

• 常用名: a2e
• 英文名: a2e
• CAS号: 173449-96-2
• 分子量: 592.91600
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₂H₅₈NO+
• 熔点: N/A
• 闪点: N/A

a2e用途

吡啶鎓双维甲酸A2E(A2E)是蓝光诱导的细胞凋亡的引发剂。吡啶鎓双维甲酸A2E的光激活介导自噬和活性氧物质的产生[1][2]。

a2e名称

• 英文名: a2e

a2e生物活性

• 描述: 吡啶鎓双维甲酸A2E(A2E)是蓝光诱导的细胞凋亡的引发剂。吡啶鎓双维甲酸A2E的光激活介导自噬和活性氧物质的产生[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
• 参考文献:

  [1]. Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555.

  [2]. S. Ben-Shabat, et al; Elucidating the Role of Pyridinium bis-Retinoid(A2E) in Retinal Pigment Epithelium (RPE) Cell Damages. Invest. Ophthalmol. Vis. Sci. 2007;48(13):2201.

a2e物理化学性质

• 分子式: C₄₂H₅₈NO+
• 分子量: 592.91600
• 精确质量: 592.45200
• PSA: 24.11000
• LogP: 10.99730

a2e英文别名

• N-retinylidene-N-retinyl-ethanolamine
• 2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]pyridinium
• N-retinyl-N-retinylidene ethanolamine
• 2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium
• (2-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium)
• N-retinylidene-N-retinylethanolamine
• 2-[(1E,3E,5E,7E)-2,6-Dimethyl-8-(2,6,6-trimethyl-cyclohex-1-enyl)-octa-1,3,5,7-tetraenyl]-1-(2-hydroxy-ethyl)-4-[(1E,3E,5E)-4-methyl-6-(2,6,6-trimethyl-cyclohex-1-enyl)-hexa-1,3,5-trienyl]-pyridinium