Glycoursodeoxycholic Acid-d4

• 常用名: Glycoursodeoxycholic Acid-d4
• 英文名: Glycoursodeoxycholic Acid-d4 MaxSpec® Standard
• CAS号: 2044276-17-5
• 分子量: 453.648
• 密度: 1.2±0.1 g/cm3
• 沸点: 655.6±40.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉D₄NO₅
• 熔点: N/A
• 闪点: 350.3±27.3 °C

Glycoursodeoxycholic Acid-d4用途

甘熊去氧胆酸-d4(熊去氧胆酸甘氨酸-d4)是氘标记的甘熊去氧胆酸。甘熊去氧胆酸是一种酰基甘氨酸和胆汁酸甘氨酸结合物,是熊去氧胆酸的代谢物[1][2]。

Glycoursodeoxycholic Acid-d4名称

• 英文名: Glycoursodeoxycholic Acid-d4 MaxSpec® Standard

Glycoursodeoxycholic Acid-d4生物活性

• 描述: 甘熊去氧胆酸-d4(熊去氧胆酸甘氨酸-d4)是氘标记的甘熊去氧胆酸。甘熊去氧胆酸是一种酰基甘氨酸和胆汁酸甘氨酸结合物,是熊去氧胆酸的代谢物[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Vaz AR, et al. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. J Neurochem. 2010 Jan;112(1):56-65.

  [3]. Vaz AR, et al. Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration.

  [4]. Palmela I, et al. Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study. Front Neurosci. 2015 Mar 13;9:80.

Glycoursodeoxycholic Acid-d4物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 655.6±40.0 °C at 760 mmHg
• 分子式: C₂₆H₃₉D₄NO₅
• 分子量: 453.648
• 闪点: 350.3±27.3 °C
• 精确质量: 453.339233
• LogP: 3.53
• 蒸汽压: 0.0±4.5 mmHg at 25°C
• 折射率: 1.546

Glycoursodeoxycholic Acid-d4英文别名

• N-[(3α,5β,7β)-3,7-Dihydroxy-24-oxo(2,2,4,4-2H4)cholan-24-yl]glycine
• Glycine, N-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-
• Glycoursodeoxycholic Acid-d4