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Fluphenazine enanthate

更新时间:2024-01-04 09:14:29

Fluphenazine enanthate结构式
Fluphenazine enanthate结构式
品牌特惠专场
常用名 Fluphenazine enanthate 英文名 Fluphenazine enanthate
CAS号 2746-81-8 分子量 549.69100
密度 1.181g/cm3 沸点 629.4ºC at 760mmHg
分子式 C29H38F3N3O2S 熔点 N/A
MSDS N/A 闪点 334.4ºC

 Fluphenazine enanthate用途


Fluphenazine enanthate 是第一种长效抗精神病药物,用于治疗精神分裂症。

 Fluphenazine enanthate名称

中文名 氟奋乃静庚酸酯
英文名 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl heptanoate
英文别名 更多

 Fluphenazine enanthate生物活性

描述 Fluphenazine enanthate 是第一种长效抗精神病药物,用于治疗精神分裂症。
相关类别
体内研究 氟奋乃静对映体(2,4,8mg/kg;IM)对回避行为的抑制作用分别持续16、23和28天[1]。氟奋乃静(8mg/kg)的饮酒行为在给药后24小时内几乎完全被抑制[1]。氟奋乃嗪(8 mg/kg)在大鼠体内产生短暂的体重损失[1]。动物模型:Wistar品系雄性成年大鼠54只[1]剂量:2、4、8mg/kg给药:中指数(IM)结果:3种剂量的氟哌嗪分别在16、23、28d时对回避行为有明显抑制作用。
参考文献

[1]. Kuribara H, et al. Effects of fluphenazine enanthate and fluphenazine decanoate on discriminated avoidanceresponse and water drinking behavior in rats. Psychopharmacology (Berl). 1979 Sep;65(1):1-6.

[2]. Brissos S, et al. The role of long-acting injectable antipsychotics in schizophrenia: a critical appraisal. Ther Adv Psychopharmacol. 2014 Oct;4(5):198-219.

 Fluphenazine enanthate物理化学性质

密度 1.181g/cm3
沸点 629.4ºC at 760mmHg
分子式 C29H38F3N3O2S
分子量 549.69100
闪点 334.4ºC
精确质量 549.26400
PSA 61.32000
LogP 6.77020
蒸汽压 9.41E-16mmHg at 25°C
折射率 1.544

 Fluphenazine enanthate毒性和生态

 Fluphenazine enanthate安全信息

危险品运输编码 UN 3249
包装等级 III
危险类别 6.1(b)

 Fluphenazine enanthate文献23

更多文献
Ten year outcomes of outpatients with schizophrenia on conventional depot antipsychotics: a systematic chart review.

Int. Clin. Psychopharmacol. 28(5) , 261-6, (2013)

Long-term follow-up data of patients with schizophrenia on depot antipsychotics have been few and the longest follow-up period has been up to 7 years. We carried out a systematic chart review to exami...

Treatment of schizophrenia with depot preparations of fluphenazine, haloperidol, and risperidone among inpatients at state-operated psychiatric facilities.

Schizophr. Res. 119(1-3) , 153-9, (2010)

This study aimed to characterize the inpatient utilization of depot antipsychotics.The characteristics of adults with schizophrenia or schizoaffective disorder, hospitalized for at least 28 days, and ...

Multiple congenital abnormalities in a newborn boy associated with maternal use of fluphenazine enanthate and other drugs during pregnancy.

Acta Paediatr. Scand. 71(2) , 335-8, (1982)

A boy was born with a short sloping forehead, wide metopic suture, persistent metopic fontanelle, telecanthus, ocular hypertelorism, nystagmoid eye movements, bilateral cleft lip and palate, imperfora...

 Fluphenazine enanthate英文别名

Fluphenazine enantate
2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl heptanoate
Fluphenazinenanthat
Fluphenanzin-aenanthat
2-[4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl heptanoate
Fluphenazin-aenanthsaeureester
4-<3-<2-Trifluormethyl-phenothiazinyl-(10)>-propyl>-1-(2-hydroxy-ethyl)-piperazin-heptanoat
1-heptanoyloxy-2-{4-[3-(2-trifluoromethyl-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethane
Moditen-retard
Prolixin Enanthate
fluphenazine enanthate
fluphenazine O-enantate
Eutimox
EINECS 220-385-0
品牌现货直购
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