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盐酸氮芥

更新时间:2024-01-02 11:28:44

盐酸氮芥结构式
盐酸氮芥结构式
品牌特惠专场
常用名 盐酸氮芥 英文名 Chlormethine hydrochloride
CAS号 55-86-7 分子量 192.514
密度 1.106g/cm3 沸点 110.3ºC at 760 mmHg
分子式 C5H12Cl3N 熔点 108-111 °C(lit.)
MSDS 中文版 美版 闪点 20.5ºC
符号 GHS05 GHS06 GHS08
GHS05, GHS06, GHS08
信号词 Danger

 盐酸氮芥用途


Chlormethine盐酸盐是一种发泡剂,对粘膜造成坏死性刺激性破坏。用在霍奇金病和淋巴瘤中抗肿瘤。

 盐酸氮芥名称

中文名 氮芥盐酸盐
英文名 mechlorethamine hydrochloride
中文别名 恩比兴 | 二氯甲基二乙胺盐酸盐 | 盐酸氮芥 | 2-氯-N-(2-氯乙基)-N-甲基乙胺盐酸盐 | N-甲基-N-(2-氯乙基)-2-氯乙胺盐酸盐
英文别名 更多

 盐酸氮芥生物活性

描述 Chlormethine盐酸盐是一种发泡剂,对粘膜造成坏死性刺激性破坏。用在霍奇金病和淋巴瘤中抗肿瘤。
相关类别
参考文献

[1]. Cao Z, et al. Effect of brentuximab vedotin combined with chlormethine hydrochloride on the treatment of 6 patients with relapsed and refractory Hodgkin lymphoma. Zhonghua Xue Ye Xue Za Zhi. 2015 Jul 14;36(7):575-577.

 盐酸氮芥物理化学性质

密度 1.106g/cm3
沸点 110.3ºC at 760 mmHg
熔点 108-111 °C(lit.)
分子式 C5H12Cl3N
分子量 192.514
闪点 20.5ºC
精确质量 191.003525
PSA 3.24000
LogP 2.19780
外观性状 白色结晶粉末
折射率 1.4689 (24ºC)
储存条件 库房通风低温干燥,与食品原料分开存放
稳定性 Stable. Hygroscopic.
计算化学

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:1

3.氢键受体数量:1

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积3.2

7.重原子数量:9

8.表面电荷:0

9.复杂度:43.7

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2

更多

1.熔点(℃):108-111。.

 盐酸氮芥MSDS

 盐酸氮芥毒性和生态

 盐酸氮芥安全信息

符号 GHS05 GHS06 GHS08
GHS05, GHS06, GHS08
信号词 Danger
危害声明 H300 + H310-H314-H340-H350-H360D
警示性声明 P201-P264-P280-P301 + P310-P302 + P350-P305 + P351 + P338
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T+:Verytoxic;
风险声明 (欧洲) R45;R46;R28;R34;R42/43
安全声明 (欧洲) S53-S36/37/39-S45
危险品运输编码 UN 2811 6.1/PG 2
WGK德国 3
RTECS号 IA2100000
包装等级 II
危险类别 6.1(a)
海关编码 2921199090

 盐酸氮芥海关

海关编码 2921199090
中文概述 2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素 品名, 成分含量, 用途
Summary 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 盐酸氮芥文献492

更多文献
Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.

Hum. Mol. Genet. 24(3) , 698-713, (2015)

Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. ...

Lethality of PAK3 and SGK2 shRNAs to human papillomavirus positive cervical cancer cells is independent of PAK3 and SGK2 knockdown.

PLoS ONE 10(1) , e0117357, (2015)

The p21-activated kinase 3 (PAK3) and the serum and glucocorticoid-induced kinase 2 (SGK2) have been previously proposed as essential kinases for human papillomavirus positive (HPV+) cervical cancer c...

Developing Adnectins that target SRC co-activator binding to PXR: a structural approach toward understanding promiscuity of PXR.

J. Mol. Biol. 427(4) , 924-42, (2015)

The human pregnane X receptor (PXR) is a promiscuous nuclear receptor that functions as a sensor to a wide variety of xenobiotics and regulates expression of several drug metabolizing enzymes and tran...

 盐酸氮芥英文别名

Ethanamine, 2-chloro-N- (2-chloroethyl)-N-methyl-, hydrochloride
n-lost
pliva
Mustargen hydrochloride
β,β'-Dichlorodiethyl-N-methylamine hydrochloride
2-Chlor-N-(2-chlorethyl)-N-methylethanaminhydrochlorid
Methyldi(β-chloroethyl)amine hydrochloride
Mechlorethamine HCl
Cloramin
2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride
Nitrogen mustard HCl
MFCD00012517
bis(2-chlorolthyl)amine hydrochloride
zagreb
EINECS 200-246-0
Methylbis(β-chloroethyl)amine hydrochloride
c6866
b,b'-Dichlorodiethyl-N-methylamine Hydrochloride
chloramin
N-Methylbis(β-chlorethyl)amine hydrochloride
dimitan
Nitrogranulogen
erasol
antimit
dichloren
Embichen
Bis(2-chloroethyl)methylamine hydrochloride
Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, hydrochloride (1:1)
Mechlorethamine hydrochloride
SK 101
2-chloro-N-(2-chloroéthyl)-N-méthyléthanamine chlorhydrate
2-Chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (1:1)
MBA hydrochloride
Chlormethine (hydrochloride)
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