索比尼尔

更新时间：2024-01-03 10:04:44

索比尼尔结构式	常用名	索比尼尔	英文名	Sorbinil
	CAS号	68367-52-2	分子量	236.19900
	密度	1.52g/cm3	沸点	N/A
	分子式	C₁₁H₉FN₂O₃	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS07	信号词	Warning

索比尼尔用途

Sorbinil 是一种醛糖还原酶抑制剂 (ARI)。Sorbinil 在治疗糖尿病和糖尿病并发症方面发挥治疗作用,降低 AR 活性和抑制多元醇途径,发现它比人类使用的其它 ARI 更安全。

中文名	索比尼尔
英文名	sorbinil
英文别名	更多

描述	Sorbinil 是一种醛糖还原酶抑制剂 (ARI)。Sorbinil 在治疗糖尿病和糖尿病并发症方面发挥治疗作用,降低 AR 活性和抑制多元醇途径,发现它比人类使用的其它 ARI 更安全。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 醛糖还原酶研究领域 >> 代谢疾病
参考文献	[1]. Huang Q, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Med Chem. 2019;15(1):3-7.

密度	1.52g/cm3
分子式	C₁₁H₉FN₂O₃
分子量	236.19900
精确质量	236.06000
PSA	67.43000
LogP	1.30050
外观性状	白色至类白色粉末
折射率	1.629
储存条件	2-8°C

符号	GHS07
信号词	Warning
危害声明	H302
危害码 (欧洲)	Xn
危险品运输编码	NONH for all modes of transport

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

PLoS ONE 7(4) , e31399, (2012)

Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase ...

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

Invest. Ophthalmol. Vis. Sci. 55(5) , 2853-61, (2014)

Retinal microglia become activated in diabetes and produce pro-inflammatory molecules associated with changes in retinal vasculature and increased apoptosis of retinal neurons and glial cells. We soug...

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

Chem. Biol. Interact. 234 , 254-60, (2015)

Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis o...

(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione

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