5-羧酰胺色胺马来酸盐结构式
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常用名 | 5-羧酰胺色胺马来酸盐 | 英文名 | 5-Carboxamidotryptamine maleate |
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CAS号 | 74885-72-6 | 分子量 | 319.31 | |
密度 | N/A | 沸点 | N/A | |
分子式 | C15H17N3O5 | 熔点 | N/A | |
MSDS | 美版 | 闪点 | N/A | |
符号 |
GHS07 |
信号词 | Warning |
5-羧酰胺色胺马来酸盐用途5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。 |
中文名 | 5-羧酰胺色胺马来酸盐 |
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英文名 | 5-Carboxamidotryptamine maleate |
英文别名 | 更多 |
描述 | 5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。 |
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相关类别 | |
靶点 |
5-HT1A Receptor 5-HT1B Receptor 5-HT1D Receptor 5-HT5 Receptor 5-HT7 Receptor |
体外研究 | 与牛黑质5-HT1D位点结合的[3H]-5-Carboxamidoryptamine(5-CT)具有快速、可逆和饱和的特点,表现出高亲和力(Kd=0.38nm)和低非特异性结合[2]。在牛黑质中,[3H]-5-甲酰胺三嗪(5-CT)标记的结合位点数量与[3H]-5-Carboxamidoryptamine(分别为403和362fmol/mg蛋白质)的结合位点,并且结合对鸟嘌呤核苷酸敏感[2]。 |
体内研究 | 暴露于硬脑膜的外用5-卡波胺(0.01-1000μM)可使麻醉Wistar大鼠的中脑膜动脉舒张压降低,脑膜血流量发生变化,传导率增加(即扩张)(5-羟色胺耗竭,用20 mg/kg皮质酮治疗)[1]。 |
参考文献 |
分子式 | C15H17N3O5 |
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分子量 | 319.31 |
外观性状 | 固体 |
储存条件 | -20°C |
符号 |
GHS07 |
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信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
危害码 (欧洲) | Xi |
危险品运输编码 | NONH for all modes of transport |
GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved?
J. Cardiovasc. Pharmacol. 65(4) , 335-41, (2015) The 5-HT1B/1D receptor antagonist, GR-127935, inhibits hypotensive responses produced by the 5-HT1A, 5-HT1B/1D and 5-HT7 receptor agonist, and 5-HT5A/5B receptor ligand, 5-carboxamidotryptamine (5-CT)... |
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Synthesis and pharmacological evaluation of optically pure, novel carbonyl guanidine derivatives as dual 5-HT2B and 5-HT7 receptor antagonists.
Bioorg. Med. Chem. 22(21) , 6026-38, (2014) A series of 9-disubstituted N-(9H-fluorene-2-carbonyl)guanidine derivatives have been discovered as potent and orally active dual 5-HT(2B) and 5-HT(7) receptor antagonists. Upon screening several comp... |
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The serotonin receptor 5-HT₇R regulates the morphology and migratory properties of dendritic cells.
J. Cell Sci. 128 , 2866-80, (2015) Dendritic cells are potent antigen-presenting cells endowed with the unique ability to initiate adaptive immune responses upon inflammation. Inflammatory processes are often associated with an increas... |
MFCD00069224 |