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5-羧酰胺色胺马来酸盐

更新时间:2024-01-03 18:34:57

5-羧酰胺色胺马来酸盐结构式
5-羧酰胺色胺马来酸盐结构式
品牌特惠专场
常用名 5-羧酰胺色胺马来酸盐 英文名 5-Carboxamidotryptamine maleate
CAS号 74885-72-6 分子量 319.31
密度 N/A 沸点 N/A
分子式 C15H17N3O5 熔点 N/A
MSDS 美版 闪点 N/A
符号 GHS07
GHS07
信号词 Warning

 5-羧酰胺色胺马来酸盐用途


5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。

 5-羧酰胺色胺马来酸盐名称

中文名 5-羧酰胺色胺马来酸盐
英文名 5-Carboxamidotryptamine maleate
英文别名 更多

 5-羧酰胺色胺马来酸盐生物活性

描述 5-Carboxamidotryptamine maleate (5-CT maleate) 是一种有效的 5-HT1A,5-HT1B,5-HT1D,5-HT5 和 5-HT7 受体激动剂。
相关类别
靶点

5-HT1A Receptor

5-HT1B Receptor

5-HT1D Receptor

5-HT5 Receptor

5-HT7 Receptor

体外研究 与牛黑质5-HT1D位点结合的[3H]-5-Carboxamidoryptamine(5-CT)具有快速、可逆和饱和的特点,表现出高亲和力(Kd=0.38nm)和低非特异性结合[2]。在牛黑质中,[3H]-5-甲酰胺三嗪(5-CT)标记的结合位点数量与[3H]-5-Carboxamidoryptamine(分别为403和362fmol/mg蛋白质)的结合位点,并且结合对鸟嘌呤核苷酸敏感[2]。
体内研究 暴露于硬脑膜的外用5-卡波胺(0.01-1000μM)可使麻醉Wistar大鼠的中脑膜动脉舒张压降低,脑膜血流量发生变化,传导率增加(即扩张)(5-羟色胺耗竭,用20 mg/kg皮质酮治疗)[1]。
参考文献

[1]. E Martínez-García, et al. 5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment. Proc West Pharmacol Soc. 2011;54:57-61.

[2]. H P Nowak, et al. [3H]-5-carboxamidotryptamine labels 5-HT1D binding sites in bovine substantia nigra. Br J Pharmacol. 1993 Aug;109(4):1206-11.

[3]. J Yamada, et al. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. Eur J Pharmacol. 1998 Oct 16;359(1):81-6.

 5-羧酰胺色胺马来酸盐物理化学性质

分子式 C15H17N3O5
分子量 319.31
外观性状 固体
储存条件 -20°C

 5-羧酰胺色胺马来酸盐安全信息

符号 GHS07
GHS07
信号词 Warning
危害声明 H315-H319-H335
警示性声明 P261-P305 + P351 + P338
个人防护装备 dust mask type N95 (US);Eyeshields;Gloves
危害码 (欧洲) Xi
危险品运输编码 NONH for all modes of transport

 5-羧酰胺色胺马来酸盐文献18

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 5-羧酰胺色胺马来酸盐英文别名

MFCD00069224
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