Timapiprant

• 常用名: Timapiprant
• 英文名: OC000459
• CAS号: 851723-84-7
• 分子量: 348.370
• 密度: 1.3±0.1 g/cm3
• 沸点: 574.4±50.0 °C at 760 mmHg
• 分子式: C₂₁H₁₇FN₂O₂
• 熔点: N/A
• 闪点: 301.2±30.1 °C

Timapiprant用途

OC000459是D型前列腺素受体2（DP2）拮抗剂，IC50为13 nM。

Timapiprant名称

• 中文名: [5-氟-2-甲基-3-(喹啉-2-基甲基)吲哚-1-基]乙酸
• 英文名: 2-(5-Fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-indol-1-yl)acetic acid

Timapiprant生物活性

• 描述: OC000459是D型前列腺素受体2(DP2)拮抗剂,IC50为13 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Singh D, Cadden P, Hunter M, Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459. Eur Respir J. 2013 Jan;41(1):46-52.

  [2]. Horak F, Zieglmayer P, Zieglmayer R, The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. Allergy. 2012 Dec;67(12):1572-9.

  [3]. Pettipher R, Vinall SL, Xue L, Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. J Pharmacol Exp Ther. 2012 Feb;340(2):473-82.

Timapiprant物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 574.4±50.0 °C at 760 mmHg
• 分子式: C₂₁H₁₇FN₂O₂
• 分子量: 348.370
• 闪点: 301.2±30.1 °C
• 精确质量: 348.127411
• PSA: 55.12000
• LogP: 4.37
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.646
• 储存条件: -20°C

Timapiprant安全信息

• 海关编码: 2933990090

Timapiprant海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Timapiprant英文别名

• [5-Fluoro-2-methyl-3-(2-quinolinylmethyl)-1H-indol-1-yl]acetic acid
• 1H-Indole-1-acetic acid, 5-fluoro-2-methyl-3-(2-quinolinylmethyl)-
• 2-[5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)indol-1-yl]acetic acid
• OC000459