JNJ-28312141
JNJ-28312141结构式
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常用名 | JNJ-28312141 | 英文名 | JNJ-28312141 |
|---|---|---|---|---|
| CAS号 | 885692-52-4 | 分子量 | 460.571 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C26H32N6O2 | 熔点 | N/A | |
| MSDS | N/A | 闪点 | N/A |
JNJ-28312141用途JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. |
| 英文名 | 5-cyano-N-[2-(cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamide |
|---|---|
| 英文别名 | 更多 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 分子式 | C26H32N6O2 |
| 分子量 | 460.571 |
| 精确质量 | 460.258667 |
| PSA | 105.12000 |
| LogP | 2.72 |
| 折射率 | 1.632 |
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JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
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~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
|
~%
JNJ-28312141 885692-52-4 |
| 文献：Illig, Carl R.; Manthey, Carl L.; Wall, Mark J.; Meegalla, Sanath K.; Chen, Jinsheng; Wilson, Kenneth J.; Ballentine, Shelley K.; Desjarlais, Renee L.; Schubert, Carsten; Crysler, Carl S.; Chen, Yanmin; Molloy, Christopher J.; Chaikin, Margery A.; Donatelli, Robert R.; Yurkow, Edward; Zhou, Zhao; Player, Mark R.; Tomczuk, Bruce E. Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7860 - 7883 |
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| JNJ-28312141上游产品 5 | |
|---|---|
| JNJ-28312141下游产品 0 | |
| 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(2-dimethylaminoacetyl)piperidin-4-yl]phenyl}amide |
| 1H-Imidazole-2-carboxamide,5-cyano-n-(2-(1-cyclohexen-1-yl)-4-(1-(2-(dimethylamino)acetyl)-4-piperidinyl)phenyl) |
| UNII-YKQ241VJ92 |
| 1H-Imidazole-2-carboxamide, 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]-4-piperidinyl]phenyl]- |
| 4-Cyano-N-{2-(1-cyclohexen-1-yl)-4-[1-(N,N-dimethylglycyl)-4-piperidinyl]phenyl}-1H-imidazole-2-carboxamide |
