Cyamemazine
Cyamemazine structure
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Common Name | Cyamemazine | ||
|---|---|---|---|---|
| CAS Number | 3546-03-0 | Molecular Weight | 323.455 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 479.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H21N3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 243.5±28.7 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Identification and quantification of 35 psychotropic drugs and metabolites in hair by LC-MS/MS: application in forensic toxicology.
Int. J. Legal Med. 129(2) , 259-68, (2015) Despite a non-invasive sampling, hair samples are generally collected in limited amounts for an obvious esthetic reason. In order to reduce the required quantity of samples, a multianalytes method allowing simultaneous identification and quantification of 35 ... |
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Fatal intoxication with milnacipran
J. Forensic Leg. Med. 15(6) , 388-90, (2008) The antidepressant milnacipran is a double serotonin/noradrenalin reuptake inhibitor. The low reported incidence of intoxication indicates excellent tolerance in comparison with tricyclic and second generation antidepressants. We report a fatal intoxication a... |
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Prise en charge médicamenteuse de l’anxiété chez le patient souffrant de schizophrénie
Encephale 37 Suppl 1 , S83-9, (2011) L’anxiété est un symptôme fréquent et majeur de la schizophrénie. Elle est un symptôme clinique dominant dans la phase prodromique [indice de progression vers la « décompensation psychotique »] et accompagne souvent le premier épisode de schizophrénie. Suite ... |
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Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine.
Eur. J. Pharm. Sci. 32(4-5) , 357-66, (2007) Recombinant human liver microsomal enzymes of the cytochrome P450 family (CYP1A2, CYP2A6, CYP3A4, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1) were used to determine the metabolic fate of the antipsychotic anxiolytic agent cyamemazine. An LC/MS-MS tandem ... |
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Potential role of cortical 5-HT(2A) receptors in the anxiolytic action of cyamemazine in benzodiazepine withdrawal.
Psychiatry Res. 198(2) , 307-12, (2012) The antipsychotic cyamemazine is a potent serotonin 5-HT(2A) receptor (5-HT(2AR)) antagonist. A positron emission tomography (PET) study in human patients showed that therapeutic doses of cyamemazine produced near saturation of 5-HT(2AR) occupancy in the fron... |
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[Acute Datura stramonium poisoning in an emergency department].
Presse Med. 36(10 Pt 1) , 1399-403, (2007) The toxic effects of Datura stramonium most often include visual and auditory hallucinations, confusion and agitation. Severe and even fatal complications (coma, respiratory distress or death in more than 5% of cases) are not rare since the lethal concentrati... |
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Primary steps of the photochemical reactions of 2-cyano-10-(3-[dimethylamino, N-oxide]-2-methylpropyl)-5-oxide-phenothiazine, the photoproduct of cyamemazine, a phototoxic neuroleptic: comparison with the sulfoxide.
Photochem. Photobiol. Sci. 5(3) , 336-42, (2006) The UVA-absorbing photoproduct resulting from the oxidation of the sulfur atom and of the side chain nitrogen of the phototoxic drug cyamemazine (CMZ) (2-cyano-10-(3-[dimethylamino]-2 methylpropyl)-phenothiazine) is a potent photodynamic photosensitizer. The ... |
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Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study.
Ther. Drug Monit. 32(6) , 757-61, (2010) Administration of cyamemazine, an antipsychotic drug with anxiolytic properties, together with other antipsychotic agents is common in patients with schizophrenia. This retrospective study investigated the effects of cyamemazine on the steady-state plasma con... |
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Double-blind study of cyamemazine and diazepam in the alcohol withdrawal syndrome.
Hum. Psychopharmacol. Clin. Exp. 20(7) , 511-9, (2005) Cyamemazine is an original phenothiazine derivative which showed similar efficacy and tolerability to lorazepam during ethanol withdrawal in mice. This study investigated cyamemazine for its efficacy and tolerability in alcohol-dependent patients electing an ... |
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Primary photochemical processes of the phototoxic neuroleptic cyamemazine: a study by laser flash photolysis and steady-state irradiation.
Photochem. Photobiol. 80(3) , 535-41, (2004) The photophysical and photochemical properties of the UV-A-absorbing phototoxic drug cyamemazine (CMZ) (2-cyano-10-(3-[dimethylamino]-2-methyl-propyl)-phenothiazine) have been investigated in neutral buffered aqueous solutions. The transient absorbances of th... |