Propiverine hydrochloride
Propiverine hydrochloride structure
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Common Name | Propiverine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 54556-98-8 | Molecular Weight | 403.942 | |
| Density | N/A | Boiling Point | 494.7ºC at 760 mmHg | |
| Molecular Formula | C23H30ClNO3 | Melting Point | 213-216ºC | |
| MSDS | Chinese USA | Flash Point | 253ºC | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Excitatory effect of propiverine hydrochloride on urethral activity in rats.
Int. J. Urol. 19(6) , 575-82, (2012) To investigate the effects of the antimuscarinic agent, propiverine, on the bladder and urethra in rats.A total of 54 female rats were given propiverine, imidafenacin (an antimuscarinic agent), or distilled water by gavage once or twice daily. After 2 weeks, ... |
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[Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy].
Hinyokika Kiyo. 57(2) , 71-6, (2011) The efficacy and safety of additional administration of propiverine were prospectively studied for naftopidil-resistant nocturia in patients with benign prostatic hypertrophy (BPH). Patients of 50 years and over with BPH who experienced nocturia twice a night... |
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An overview on mixed action drugs for the treatment of overactive bladder and detrusor overactivity.
Urol. Int. 89(3) , 259-69, (2012) To provide an overview on the efficacy, tolerability, safety and health-related quality of life (HRQoL) of drugs with a mixed action used in the treatment of overactive bladder (OAB).MEDLINE database and abstract books of the major conferences were searched f... |
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Propiverine: a review of its use in the treatment of adults and children with overactive bladder associated with idiopathic or neurogenic detrusor overactivity, and in men with lower urinary tract symptoms.
Clin. Drug Investig. 33(1) , 71-91, (2013) Propiverine is a well established antimuscarinic agent with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). As well as blocking muscarinic receptors in the detrusor muscle, the drug also inhibits cellular calcium ... |
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Efficacy of propiverine, an anticholinergic agent, in young and old rats.
Life Sci. 89(13-14) , 456-9, (2011) We examined the influence of propiverine hydrochloride, an anticholinergic agent, on the micturition reflex, blood pressure, and plasma catecholamine levels in young rats and old rats.Male F344/DuCrlCrlj Fischer rats (young rats aged 2 months and old rats age... |
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Oxybutynin and propiverine suppress adenosine triphosphate-induced bladder overactivity other than through antimuscarinic mechanisms.
Urology 76(2) , 509.e8-12, (2010) Adenosine triphosphate (ATP) is released from bladder urothelium in response to stretch and may act as a sensory neurotransmitter. ATP release from the bladder urothelium is augmented in many pathophysiologic conditions, resulting in bladder overactivity. Pat... |
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Urodynamic effects of propiverine in children and adolescents with neurogenic bladder: Results of a prospective long-term study
J. Pediatr. Urol. 8(4) , 386-92, (2012) Objective To evaluate prospectively the efficacy and tolerability of propiverine for long-term treatment of neurogenic detrusor overactivity (NDO) in children. |
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The influence of propiverine hydrochloride on cardiac repolarization in healthy women and cardiac male patients.
Int. J. Clin. Pharmacol. Ther. 49(6) , 353-65, (2011) Two comprehensively designed mono-centric ECG studies were performed to investigate the influence of propiverine hydrochloride and its main metabolite propiverine-N-oxide on cardiac function with regard to QTc prolongation, QTc dispersion and T-wave shape.The... |
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Determination of propiverine hydrochloride in human plasma by high performance liquid chromatography-tandem mass spectrometry: application to the pharmacokinetic study of a sustained release formulation.
Arzneimittelforschung 61(9) , 494-501, (2011) A rapid, sensitive and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and validated for the determination of propiverine hydrochloride (CAS 54556-98-8) in human plasma using cetirizine di-hydrochlori... |
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Editorial comment from Dr Sekido to propiverine hydrochloride in Japanese patients with overactive bladder: a randomized, double-blind, placebo-controlled trial.
Int. J. Urol. 18(5) , 373-4, (2011)
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