(S)-(?)-Perillyl alcohol
(S)-(?)-Perillyl alcohol structure
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Common Name | (S)-(?)-Perillyl alcohol | ||
|---|---|---|---|---|
| CAS Number | 18457-55-1 | Molecular Weight | 152.233 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 241.2±19.0 °C at 760 mmHg | |
| Molecular Formula | C10H16O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 99.6±17.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer.
Adv. Exp. Med. Biol. 401 , 131-6, (1996) Perillyl alcohol is a natural product from cherries and other edible plants. Perillyl alcohol and d-limonene, a closely related dietary monoterpene, have chemotherapeutic activity against pancreatic, mammary, and prostatic tumors. In addition, perillyl alcoho... |
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The promise of natural products for blocking early events in skin carcinogenesis.
Cancer Prev. Res. (Phila.) 3(2) , 132-5, (2010) This perspective on Stratton et al. (beginning on p. 160), Kowalczyk et al. (beginning on p. 170), and Katiyar et al. (beginning on p. 179) highlights the common theme of translational investigation of natural substances and their molecular effects and mechan... |
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Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
J. Ind. Microbiol. Biotechnol. 38(9) , 1359-70, (2011) Cell physiology is a critical factor determining the efficiency of reactions performed by microbial biocatalysts. In order to develop an efficient biotransformation procedure for the hydroxylation of (S)-limonene to (S)-perillyl alcohol by recombinant Pseudom... |
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Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities.
Blood 119(11) , 2568-78, (2012) Although bortezomib is clinically approved for the treatment of mantle cell lymphoma (MCL), only limited effects of this treatment have been demonstrated. To improve survival for bortezomib-resistant patients, it is necessary to develop new therapeutic strate... |
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Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol.
J. Proteomics 73(5) , 1018-27, (2010) Perillyl alcohol (POH) is a naturally occurring terpene and a promising chemotherapeutic agent for glioblastoma multiform; yet, little is known about its molecular effects. Here we present results of a semi-quantitative proteomic analysis of A172 cells expose... |
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Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin.
Anticancer Drugs 21(1) , 1-9, (2010) Breast cancer is the second leading cause of cancer deaths among women in the United States. Several treatment options exist, with different side effects. To alleviate the side effects, several research groups have studied chemotherapeutic effects of plant co... |
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Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma.
Nutr. Cancer 61(5) , 640-8, (2009) Mastic oil from Pistacia lentiscus variation chia, a traditionally used dietary flavoring agent with medicinal properties, has been shown to exert in vitro antitumor activities, but no study has addressed in vivo efficacy and mechanisms of action. Presently, ... |
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The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells.
Biochimie 94(12) , 2639-48, (2012) Isoprenoids are recognized for their ability to suppress carcinogenic processes in vivo and in vitro. We previously established that the isoprenoid, perillyl alcohol, acted mechanistically on translation of specific proteins through modulation of mechanistic ... |
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Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin.
Mol. Cell Biochem. 375(1-2) , 97-104, (2013) We previously demonstrated in prostate cancer cells that a phytochemical-perillyl alcohol-and the mechanistic target of rapamycin (mTOR) inhibitor rapamycin rapidly attenuated telomerase activity. Protein levels of the telomerase catalytic subunit reverse tra... |
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Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy.
J. Cancer Res. Clin. Oncol. 138(8) , 1347-54, (2012) Malignant gliomas are associated with alteration in EGF/EGFR signaling. Functional EGF+61A>G polymorphism is implicated with risk, recurrence, and progression of glioma. This study aimed to establish a putative association of EGF+61A>G with risk of glioma dev... |