mersalyl acid
mersalyl acid structure
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Common Name | mersalyl acid | ||
|---|---|---|---|---|
| CAS Number | 486-67-9 | Molecular Weight | 483.86700 | |
| Density | N/A | Boiling Point | 467.9ºC at 760mmHg | |
| Molecular Formula | C13H17HgNO6 | Melting Point | 192-193ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 236.7ºC | |
| Symbol |
GHS06, GHS08, GHS09 |
Signal Word | Danger | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Interaction of mitochondrial phosphate carrier with fatty acids and hydrophobic phosphate analogs.
Int. J. Biochem. Cell Biol. 32(5) , 499-508, (2000) Mitochondrial transporters, in particular uncoupling proteins and the ADP/ATP carrier, are known to mediate uniport of anionic fatty acids (FAs), allowing FA cycling which is completed by the passive movement of FAs across the membrane in their protonated for... |
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Reactive oxygen species inhibit the succinate oxidation-supported generation of membrane potential in wheat mitochondria.
FEBS Lett. 516(1-3) , 15-9, (2002) In order to gain a first insight into the effects of reactive oxygen species (ROS) on plant mitochondria, we studied the effect of the ROS producing system consisting of xanthine plus xanthine oxidase on the rate of membrane potential (DeltaPsi) generation du... |
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High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units
Biochim. Biophys. Acta 1807(12) , 1549-61, (2011) The aim of our study was to analyze a distribution of metabolic flux controls of all mitochondrial complexes of ATP-Synthasome and mitochondrial creatine kinase (MtCK) in situ in permeabilized cardiac cells. For this we used their specific inhibitors to measu... |
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Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease.
Biochim. Biophys. Acta 1827(7) , 848-60, (2013) To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Aβ1-42 is due to an interplay between these two Alzheimer's peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thio... |
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The effects of singlet oxygen produced by photodynamic action on the mitochondrial permeability transition differ in accordance with the localization of the sensitizer.
Arch. Biochem. Biophys. 386(2) , 243-50, (2001) We have examined whether the effects of singlet oxygen (1O2) produced by photodynamic action on the mitochondrial permeability transition (PT) can be modulated by the localization of photosensitizers in irradiated mitochondria. We have previously shown that o... |
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Glutamine transport in rat brain synaptic and non-synaptic mitochondria.
Neurochem. Res. 24(3) , 383-90, (1999) Glutamine transport into rat brain mitochondria (synaptic and non-synaptic) was monitored by the uptake of [3H]glutamine as well as by mitochondrial swelling. The uptake is inversely correlated to medium osmolarity, temperature-dependent, saturable and inhibi... |
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Membrane-initiated steroid signaling (MISS): genomic steroid action starts at the plasma membrane.
J. Steroid Biochem. Mol. Biol. 85(1) , 9-23, (2003) Plasma membrane (PM) steroid recognition sites are thought to be responsible only for rapid, non-genomic responses without any link to the nuclear receptor-mediated genomic effects of steroids. We focused on a PM "glucocorticoid-importer" (GC-importer) that i... |
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Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila.
J. Biol. Chem. 276(4) , 2432-9, (2001) Heterodisulfide reductase (HDR) is a component of the energy-conserving electron transfer system in methanogens. HDR catalyzes the two-electron reduction of coenzyme B-S-S-coenzyme M (CoB-S-S-CoM), the heterodisulfide product of the methyl-CoM reductase react... |
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Elucidating the role of conserved glutamates in H+-pyrophosphatase of Rhodospirillum rubrum.
J. Biol. Chem. 279(26) , 26811-6, (2004) H(+)-pyrophosphatase (H(+)-PPase) catalyzes pyrophosphate-driven proton transport against the electrochemical potential gradient in various biological membranes. All 50 of the known H(+)-PPase amino acid sequences contain four invariant glutamate residues. In... |