Caffeine
Caffeine structure
|
Common Name | Caffeine | ||
|---|---|---|---|---|
| CAS Number | 58-08-2 | Molecular Weight | 194.191 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 416.8±37.0 °C at 760 mmHg | |
| Molecular Formula | C8H10N4O2 | Melting Point | 234-236.5 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 205.9±26.5 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster.
PLoS ONE 10(2) , e0117328, (2015) Caffeine (1, 3, 7-trimethylxanthine), an alkaloid produced by plants, has antioxidant and insecticide properties that can affect metabolism and cognition. In vertebrates, the metabolites derived from caffeine have been identified, and their functions have bee... |
|
|
Effect of caffeine treatment before vitrification on MPF and MAPK activity and spontaneous parthenogenetic activation of in vitro matured ovine oocytes.
Cryo. Letters 35(6) , 530-6, (2015) Molecules that stabilize protein kinases may be useful in overcoming the deleterious effects of cryopreservation.To evaluate the effect of caffeine treatment before vitrification of in vitro matured ovine oocytes on the activity of MPF and MAPK as well as the... |
|
|
Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair.
PLoS ONE 9(10) , e110522, (2014) 53BP1 regulates DNA double-strand break (DSB) repair. In functional assays for specific DSB repair pathways, we found that 53BP1 was important in the conservative non-homologous end-joining (C-NHEJ) pathway, and this activity was dependent upon RNF8 and RNF16... |
|
|
Ram seminal plasma proteins contribute to sperm capacitation and modulate sperm-zona pellucida interaction.
Theriogenology 83(4) , 670-8, (2015) Incubation of ram spermatozoa in capacitating conditions with cAMP-elevating agents promotes a progressive time-dependent increase in the capacitated sperm subpopulation. In this study, the fertilizing capacity of ram spermatozoa (ability to bind to the zona ... |
|
|
Metabolic study of androsta-1,4,6-triene-3,17-dione in horses using liquid chromatography/high resolution mass spectrometry.
J. Steroid Biochem. Mol. Biol. 152 , 142-54, (2015) Androsta-1,4,6-triene-3,17-dione (ATD) is an irreversible steroidal aromatase inhibitor and is marketed as a supplement. It has been reported to effectively reduce estrogen biosynthesis and significantly increase the levels of endogenous steroids such as dihy... |
|
|
Position-Specific Isotope Analysis of Xanthines: A (13)C Nuclear Magnetic Resonance Method to Determine the (13)C Intramolecular Composition at Natural Abundance.
Anal. Chem. 87 , 6600-6, (2015) The natural xanthines caffeine, theobromine, and theophylline are of major commercial importance as flavor constituents in coffee, cocoa, tea, and a number of other beverages. However, their exploitation for authenticity, a requirement in these commodities th... |
|
|
Phosphorylation within the cysteine-rich region of dystrophin enhances its association with β-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting.
Hum. Mol. Genet. 23(25) , 6697-711, (2014) Mutations in dystrophin lead to Duchenne muscular dystrophy, which is among the most common human genetic disorders. Dystrophin nucleates assembly of the dystrophin-glycoprotein complex (DGC), and a defective DGC disrupts an essential link between the intrace... |
|
|
Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation.
Biomaterials 60 , 82-91, (2015) A hallmark of mature mammalian ventricular myocardium is a positive force-frequency relationship (FFR). Despite evidence of organotypic structural and molecular maturation, a positive FFR has not been observed in mammalian tissue engineered heart muscle. We h... |
|
|
Latex of Euphorbia antiquorum-induced S-phase arrest via active ATM kinase and MAPK pathways in human cervical cancer HeLa cells.
Environ. Toxicol. 30 , 1205-15, (2015) Latex of Euphorbia antiquorum (EA) has demonstrated great chemotherapeutic potential for cancer. However, the mechanisms of anti-proliferation of EA on cancer cell remain to be further investigated. The purpose of this study was to explore the influence of EA... |
|
|
The Hippo pathway promotes cell survival in response to chemical stress.
Cell Death Differ. 22 , 1526-39, (2015) Cellular stress defense mechanisms have evolved to maintain homeostasis in response to a broad variety of environmental challenges. Stress signaling pathways activate multiple cellular programs that range from the activation of survival pathways to the initia... |