SCD1-IN-1

Modify Date: 2024-01-02 17:59:21

SCD1-IN-1 structure	Common Name	SCD1-IN-1
	CAS Number	1111078-63-7	Molecular Weight	395.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀F₃NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SCD1-IN-1

SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].

Name	SCD1-IN-1

Description	SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Stearoyl-CoA Desaturase (SCD) Research Areas >> Inflammation/Immunology
Target	SCD1[1].
In Vitro	SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM[1].
In Vivo	SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model[1]. Animal Model: Hamster ear model[1] Dosage: 1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL. Administration: Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks. Result: Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
References	[1]. Li Jin, et al. Phenoxy-pyrrolidine derivative and its use and compositions Patent. WO2009019566.

Molecular Formula	C₂₀H₂₀F₃NO₄
Molecular Weight	395.37