Liothyronine-13C9,15N

Modify Date: 2024-01-17 13:39:55

Liothyronine-13C9,15N structure	Common Name	Liothyronine-13C9,15N
	CAS Number	1213569-04-0	Molecular Weight	660.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁₃C₉H₁₂I₃₁₅NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Liothyronine-13C9,15N

Liothyronine-13C9,15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].

Name	Liothyronine-13C9,15N

Description	Liothyronine-13C9,15N is the 13C and 15N labeled Liothyronine[1]. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[2][3][4].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. [3]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31195(1):385-92. [4]. Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 120(11):3622-34.

Molecular Formula	C₆₁₃C₉H₁₂I₃₁₅NO₄
Molecular Weight	660.90

Liothyronine-13C9,15N

Use of Liothyronine-13C9,15N

Names

Liothyronine-13C9,15N Biological Activity

Chemical & Physical Properties