Name | 3,3',5-triiodo-L-thyronine |
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Synonyms |
3,3',5 TRIIODOTHYRONINE (T3), IRMM STANDARD
3,5,3′-tri-iodo-l-thyronine Liothyronine (T3) T3, O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO-L-TYROSINE O-(4-Hydroxy-3-iodophenyl)-3,5-diiodotyrosine L-TYROSINE,O-(4-HYDROXY-3-IODOPHENYL)-3,5-DIIODO- Alanine, 3-[4- (4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-, L- L T3 Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine 3,3',5-Triiodothyronine Triiodothyronine L-3-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]alanine 3,5,3′-Triiodo-L-thyronine 3,3',5'-TRIIODO-DL-THYRONINE L-3,3',5-triiodo-Thyronine T 3 (S)-2-Amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoic acid EINECS 229-999-3 MFCD00036864 O-(4-hydroxy-3-iodo-phenyl)-3,5-diiodo-L-tyrosine 3,5,3'-TRIIODO-L-THYRONINE L-triiodothyronine L-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-Alanine 3,3',5'-TRIIODO-L-THYRONINE 3,3',5-TRIIODO-L-THYRONINE, FREE ACID 3,3',5-Triiodo-L-thyronine L-3,3',5-TRIIODOTHYRONINE, FREE ACID LIOTHYRONINE-D3 (2S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid LIOTHYRONINE |
Description | 3,3',5-Triiodo-L-thyronine is a potent agonist of thyroid hormone receptors TRα and TRβ with Kis of 2.3 nM. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | 3,3',5-Triiodo-L-thyronine (T3, 100 nM) stimulates the proliferation of hepatocarcinema cells in which TRβ1 is overexpressed[1]. 3,3',5-Triiodo-L-thyronine binds to human β1 thyroid hormone receptor (hTRβ1), and change its conformation. 3,3',5-Triiodo-L-thyronine promotes growth, induces differentiation and regualtes metabolic effects[2]. |
Cell Assay | Thyroid hormone depleted (Td) serum is prepared. The growth of hepatocarcinoma cells in methylcellulose is performed. To determine the effect of 3,3',5-Triiodo-L-thyronine (T3) on the growth of cells, cells are plated at a density of 3 × l04 cells/60 mm dish on day 0, and incubated in medium containing 5% regular serum, 5% Td or 5% Td and 100 nM T3. The colony formation in methylcellulose is scored 3 weeks after initial plating[1]. |
References |
Density | 2.4±0.1 g/cm3 |
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Boiling Point | 563.5±50.0 °C at 760 mmHg |
Melting Point | 234-238 °C(lit.) |
Molecular Formula | C15H12I3NO4 |
Molecular Weight | 650.974 |
Flash Point | 294.6±30.1 °C |
Exact Mass | 650.790039 |
PSA | 92.78000 |
LogP | 5.08 |
Vapour Pressure | 0.0±1.6 mmHg at 25°C |
Index of Refraction | 1.763 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS02, GHS06, GHS08 |
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Signal Word | Danger |
Hazard Statements | H225-H301 + H311 + H331-H370 |
Precautionary Statements | P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi:Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | S36-S26 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | AY6750000 |
HS Code | 2922509090 |
~% 6893-02-3 |
Literature: Biochemical Journal, , vol. 53, p. 645,647 |
Precursor 1 | |
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DownStream 2 | |
HS Code | 2922509090 |
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Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |