syringomycin E

Modify Date: 2024-01-11 17:08:01

syringomycin E Structure
syringomycin E structure
Common Name syringomycin E
CAS Number 124888-22-8 Molecular Weight 1225.78000
Density 1.47g/cm3 Boiling Point N/A
Molecular Formula C53H85ClN14O17 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of syringomycin E


Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation[1][2].

 Names

Name syringomycin E
Synonym More Synonyms

 syringomycin E Biological Activity

Description Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K+ efflux, Ca2+ influx, and changes in membrane potential, and is related to channel formation[1][2].
Related Catalog
In Vitro Syringomycin E (0.5 μg/mL, 1 μg/mL; 48 h) 对酿酒酵母菌株 SS33 和 SS56 有抑制作用[1]。 Syringomycin E 是一种离子通道型,对电势跨膜分布的变化敏感[2]。
References

[1]. Stock SD, et al. Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother. 2000 May;44(5):1174-80.  

[2]. Efimova SS, et al. Alkaloids Modulate the Functioning of Ion Channels Produced by Antimicrobial Agents via an Influence on the Lipid Host. Front Cell Dev Biol. 2020 Jun 30;8:537.  

 Chemical & Physical Properties

Density 1.47g/cm3
Molecular Formula C53H85ClN14O17
Molecular Weight 1225.78000
Exact Mass 1224.59000
PSA 522.86000
LogP 0.18720
Index of Refraction 1.641

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
RIDADR NONH for all modes of transport

 Articles24

More Articles
Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae.

FEMS Microbiol. Lett. 358(1) , 64-71, (2014)

Syringomycin E is a cyclic lipodepsipeptide produced by strains of the plant bacterium Pseudomonas syringae pv. syringae. Genetic studies involving the yeast Saccharomyces cerevisiae have revealed tha...

Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels.

Langmuir 23(13) , 6889-92, (2007)

We evaluated the effect of agents modifying the membrane dipole potential: phloretin, 6-ketocholestanol and RH 421 on the properties of single channels formed by lipodepsipeptide syringomycin E (SRE) ...

[Transport of large organic ions through syringomycin channels in the membranes containing dipole modifiers].

Tsitologiia 53(5) , 450-6, (2011)

The effect of the membrane dipole potential (Phid) on a conductance and a steady-state number of functioning channels formed by cyclic lipodepsipeptide syringomycin E (SRE) in bilayer lipid membranes ...

 Synonyms

SYRINGOMYCIN E FROM PSEUDOMONAS SYRINGAE B-301D
syringomycin-E