Ribociclib-d8

Modify Date: 2024-01-17 11:02:22

Ribociclib-d8 structure	Common Name	Ribociclib-d8
	CAS Number	2167898-24-8	Molecular Weight	442.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₂D₈N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ribociclib-d8

Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].

Name	Ribociclib-d8

Description	Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10. [3]. Rader J, et al. Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma. Clin Cancer Res. 2013 Nov 1519(22):6173-82.

Molecular Formula	C₂₃H₂₂D₈N₈O
Molecular Weight	442.59

Ribociclib-d8

Use of Ribociclib-d8

Names

Ribociclib-d8 Biological Activity

Chemical & Physical Properties