KRAS inhibitor-14

Modify Date: 2024-01-10 17:09:45

KRAS inhibitor-14 structure	Common Name	KRAS inhibitor-14
	CAS Number	2230873-78-4	Molecular Weight	486.77
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₅Cl₃FN₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KRAS inhibitor-14

KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

Name	KRAS inhibitor-14

Description	KRAS inhibitor-14 (compound 3-22) is a potent KRAS G12C inhibitor with an IC50 of 0.249 µM. KRAS inhibitor-14 shows p-ERK inhibition activities with IC50s of 1.12, >33.3 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-14 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C:0.249 μM (IC50)
References	[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Molecular Formula	C₂₀H₁₅Cl₃FN₃O₂S
Molecular Weight	486.77

KRAS inhibitor-14

Use of KRAS inhibitor-14

Names

KRAS inhibitor-14 Biological Activity

Chemical & Physical Properties