HIV-1 inhibitor-21

Modify Date: 2024-01-04 17:22:17

HIV-1 inhibitor-21 structure	Common Name	HIV-1 inhibitor-21
	CAS Number	2554620-04-9	Molecular Weight	476.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₄N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HIV-1 inhibitor-21

HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

Name	HIV-1 inhibitor-21

Description	HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):12.7 nM (EC50) HIV-1 (K103N):10.4 nM (EC50)
References	[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Molecular Formula	C₂₈H₂₄N₆O₂
Molecular Weight	476.53

HIV-1 inhibitor-21

Use of HIV-1 inhibitor-21

Names

HIV-1 inhibitor-21 Biological Activity

Chemical & Physical Properties