Thalidomide-5-PEG4-NH2 hydrochloride

Modify Date: 2024-01-19 07:51:00

Thalidomide-5-PEG4-NH2 hydrochloride structure	Common Name	Thalidomide-5-PEG4-NH2 hydrochloride
	CAS Number	2743434-24-2	Molecular Weight	485.92
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₈ClN₃O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide-5-PEG4-NH2 hydrochloride

Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-5-PEG4-NH2 hydrochloride

Description	Thalidomide-5-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.

Molecular Formula	C₂₁H₂₈ClN₃O₈
Molecular Weight	485.92