NHE3-IN-3

Modify Date: 2024-04-06 07:24:59

NHE3-IN-3 structure	Common Name	NHE3-IN-3
	CAS Number	543734-50-5	Molecular Weight	371.28
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆Cl₂N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NHE3-IN-3

NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].

Name	NHE3-IN-3

Description	NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease
Target	pIC50: 6.6 (rat NHE3), 6.2 (human NHE3)[1]
References	[1]. Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051.

Molecular Formula	C₁₆H₁₆Cl₂N₂O₂S
Molecular Weight	371.28