Antitumor agent-60

Modify Date: 2024-01-04 09:48:50

Antitumor agent-60 Structure
Antitumor agent-60 structure
Common Name Antitumor agent-60
CAS Number 865784-65-2 Molecular Weight 508.54
Density N/A Boiling Point N/A
Molecular Formula C24H28O10S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Antitumor agent-60


Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].

 Names

Name Antitumor agent-60

 Antitumor agent-60 Biological Activity

Description Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].
Related Catalog
Target

IC50: 12 nM in A549, 19 nM in OVCaR-3, 29 nM in SGC-7901, 22 nM in HCT-116[1] Kd: 721.3 nM (CRAF RBD)[1]

References

[1]. Liu Z, et al. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance. Eur J Med Chem. 2020;194:112269.

 Chemical & Physical Properties

Molecular Formula C24H28O10S
Molecular Weight 508.54