Antitumor agent-60 structure
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Common Name | Antitumor agent-60 | ||
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CAS Number | 865784-65-2 | Molecular Weight | 508.54 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H28O10S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Antitumor agent-60Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1]. |
Name | Antitumor agent-60 |
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Description | Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1]. |
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Related Catalog | |
Target |
IC50: 12 nM in A549, 19 nM in OVCaR-3, 29 nM in SGC-7901, 22 nM in HCT-116[1] Kd: 721.3 nM (CRAF RBD)[1] |
References |
Molecular Formula | C24H28O10S |
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Molecular Weight | 508.54 |