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Luotonin A

Names

[ CAS No. ]:
205989-12-4

[ Name ]:
Luotonin A

[Synonym ]:
Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one
3,2'-monomethylene-2-(quinol-2-yl)-4(3H)-quinazolinone
LUOTONIN A
11,13-dihydroquino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11-one
Luotonine A
luotonin
Quinolino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one

Biological Activity

[Description]:

Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity[1][2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[References]

[1]. Hao Y, et al. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents. J Agric Food Chem. 2020 Aug 19;68(33):8764-8773.  

[2]. Cagir A, et al. A naturally occurring human DNA topoisomerase I poison. J Am Chem Soc. 2003 Nov 12;125(45):13628-9.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
530.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H11N3O

[ Molecular Weight ]:
285.30

[ Flash Point ]:
274.9±32.9 °C

[ Exact Mass ]:
285.090210

[ PSA ]:
47.78000

[ LogP ]:
2.25

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.792

Related Compounds