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DB1113

Names

[ CAS No. ]:
2769753-53-7

[ Name ]:
DB1113

Biological Activity

[Description]:

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K
Signaling Pathways >> MAPK/ERK Pathway >> MAPKAPK2 (MK2)
Research Areas >> Others
Signaling Pathways >> Apoptosis >> Ferroptosis
Signaling Pathways >> Autophagy >> ULK
Signaling Pathways >> Cell Cycle/DNA Damage >> LIM Kinase (LIMK)
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)

[Target]

CDK4

CDK11B

MAP4K2

SIK2

SIK3

MAP4K5

HPK1

GLK/MAP4K3

ULK1

LIMK1


[References]

[1]. Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.

Chemical & Physical Properties

[ Molecular Formula ]:
C59H68F3N13O6S

[ Molecular Weight ]:
1144.31

Related Compounds