HSP90-IN-14

Names

[ CAS No. ]:
1995132-67-6

[ Name ]:
HSP90-IN-14

Biological Activity

[Description]:

HSP90-IN-14 (compound 4) is a potent Hsp90 (heat shock protein 90) inhibitor, with a Kd of 0.26 μM. HSP90-IN-14 shows anti-influenza virus activity in MDCK cells, with EC50 values of 2.6, 3.9, and 17 μM for influenza A/H3N2, A/H1N1, and B, respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

HSP90β:0.26 ± 0.0 μM (Kd)


[In Vitro]

HSP90-IN-14 (compound 4) (50 µM) inhibits influenza virus-induced cytopathic effect at non-toxic concentrations[1].

[References]

[1]. Lamut A, et al. Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90. Bioorg Chem. 2020 May;98:103733.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H8Cl2N4O4S

[ Molecular Weight ]:
399.21

Related Compounds