MEK/PI3K-IN-1
Names
[ CAS No. ]:
2281803-28-7
[ Name ]:
MEK/PI3K-IN-1
Biological Activity
[Description]:
MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].
[Related Catalog]:
[Target]
MEK1:124 ± 11 nM (IC50)
PI3Kα:130 ± 13 nM (IC50)
PI3Kδ:236 ± 29 nM (IC50)
PI3Kβ:1537 ± 188 nM (IC50)
PI3Kγ:2745 ± 485 nM (IC50)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C36H37F5IN9O6
[ Molecular Weight ]:
913.63