HBV-IN-21

Names

[ CAS No. ]:
2460957-52-0

[ Name ]:
HBV-IN-21

Biological Activity

[Description]:

HBV-IN-21 (Compound II-8b) is an HBV DNA replication inhibitor with an IC50 of 2.2 µM. HBV-IN-21 can interact HBV 4 capsid protein with good affinity (KD = 60.0 μM)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[Target]

IC50: 2.2 µM (HBV DNA replication)[1]


[References]

[1]. Jia H, et al. Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors. Eur J Med Chem. 2020 Sep 15;202:112495.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H17FN4OS2

[ Molecular Weight ]:
376.47

Related Compounds