FLT3/ITD-IN-4

Names

[ CAS No. ]:
2278278-04-7

[ Name ]:
FLT3/ITD-IN-4

Biological Activity

[Description]:

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K
Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK16/Cyclin Y:1768 nM (EC50)

MAP4K4:5737 nM (EC50)

FLT3-ITD:2.3 nM (IC50)

FLT3 D835Y:4.84 nM (IC50)

RET:277 nM (EC50)

FLT3:443 nM (EC50)

ZAK/MLTK:1069 nM (EC50)

DDR2:2494 nM (EC50)

EPHA7:3255 nM (EC50)

NTRK1:3857 nM (EC50)


[References]

[1]. Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H22N4O5

[ Molecular Weight ]:
458.47

Related Compounds