210580-75-9

210580-75-9 structure

Name: 1-[(2S)-2-Aminopropyl]-1H-indazol-6-ol
Chemical Name: 1-[(2S)-2-aminopropyl]-2H-indazol-6-one
CAS Number: 210580-75-9
Molecular Formula: C₁₀H₁₃N₃O
Molecular Weight: 191.23
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-07-27 05:58:17
Modify Date: 2024-01-28 18:37:28
AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].

Name	1-[(2S)-2-aminopropyl]-2H-indazol-6-one
Synonyms	1-[(2S)-2-Aminopropyl]-1H-indazol-6-ol 1-((S)-2-Amino-propyl)-1H-indazol-6; -ol 1-((S)-2-aminopropyl)-1H-indazol-6-ol 1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-

Description	AL-34662 is a selective 5-HT2A receptoragonist (IC50: 0.77 nM and 1.5 nM for rat and human 5-HT2 receptor). AL-34662 is also a weak α-1D adrenergic agonist activity (EC50:0.4 μM). AL-34662 is an ocular hypotensive agent[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	0.77 nM and 1.5 nM for rat and human 5-HT2 receptor[1]
References	[1]. Sharif NA, et al. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. J Ocul Pharmacol Ther. 2007 Feb;23(1):1-13. [2]. Asano T, et al. Ameliorative effect of chlorpromazine hydrochloride on visceral hypersensitivity in rats: possible involvement of 5-HT2A receptor. Br J Pharmacol. 2017 Oct;174(19):3370-3381.