1093851-63-8

1093851-63-8 structure
1093851-63-8 structure
  • Name: Oseltamivir-d5
  • Chemical Name: 1,1,2,2,2-pentadeuterioethyl (3R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate
  • CAS Number: 1093851-63-8
  • Molecular Formula: C16H23D5N2O4
  • Molecular Weight: 317.43500
  • Catalog: Signaling Pathways Anti-infection Influenza Virus
  • Create Date: 2017-10-19 05:52:52
  • Modify Date: 2024-02-08 11:14:29
  • Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].

Name 1,1,2,2,2-pentadeuterioethyl (3R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate
Description Oseltamivir-d5 is the deuterium labeled Oseltamivir[1]. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50 of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. O Ferraris, et al. Sensitivity of Influenza Viruses to Zanamivir and Oseltamivir: A Study Performed on Viruses Circulating in France Prior to the Introduction of Neuraminidase Inhibitors in Clinical Practice. Antiviral Res. 2005 Oct;68(1):43-8.  

Molecular Formula C16H23D5N2O4
Molecular Weight 317.43500
Exact Mass 317.23600
PSA 94.14000
LogP 2.82600