- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Spironolactone
- Price: ￥178.0/1g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: SC9420
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Spironolactone
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
52-01-7
52-01-7 structure
- Name: Spironolactone
- Chemical Name: Spironolactone
- CAS Number: 52-01-7
- Molecular Formula: C24H32O4S
- Molecular Weight: 416.573
- Catalog: API Urinary system medication Diuretic
- Create Date: 2018-02-06 08:00:00
- Modify Date: 2024-01-02 17:40:31
-
Spironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2].
| Name | Spironolactone |
|---|---|
| Synonyms |
Spirolakton
Aldopur Osiren Sagisal Laractone Suracton Diatensec MFCD00082250 spironolactone Deverol S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate Supra-puren Aquareduct Lacalmin Ethanethioic acid, S-[(7R,8R,9S,10R,13S,14S,17R)-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-10,13-dimethyl-3,5'-dioxospiro[17H-cyclopenta[a]phenanthrene-17,2'(3'H)-furan]-7-yl] ester Nefurofan Aldace Duraspiron (7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone EINECS 200-133-6 Osyrol Lacdene SPIRONOLACTONE A Aldactone Spiroderm Spiretic 17-Hydroxy-7a-mercapto-3-oxo-17a-pregn-4-ene-21-carboxylic Acid g-Lactone Acetate S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-Dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate 3-(3-Oxo-7a-acetylthio-17b-hydroxy-4-androsten-17a-yl)propionic Acid g-Lactone Altex Spirolone Almatol Sincomen |
| Description | Spironolactone is a potent antagonist of the androgen receptor. Target: Androgen ReceptorSpironolactone is a potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT. At the concentrations used the effect has been only local. No side-effects were recorded during both studies [1]. Patients who received spironolactone had a significant improvement in the symptoms of heart failure, as assessed on the basis of the New York Heart Association functional class (P<0.001). Gynecomastia or breast pain was reported in 10 percent of men who were treated with spironolactone, as compared with 1 percent of men in the placebo group (P<0.001). The incidence of serious hyperkalemia was minimal in both groups of patients [2]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 597.0±50.0 °C at 760 mmHg |
| Melting Point | 207-208 °C(lit.) |
| Molecular Formula | C24H32O4S |
| Molecular Weight | 416.573 |
| Flash Point | 302.3±18.1 °C |
| Exact Mass | 416.202118 |
| PSA | 85.74000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.586 |
| Water Solubility | practically insoluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P280-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R40;R60 |
| Safety Phrases | 53-22-36/37/39-45-36-26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | TU4725000 |
| HS Code | 2937290090 |
|
~63%
52-01-7 |
| Literature: Wuts, Peter G. M.; Ritter, Allen R. Journal of Organic Chemistry, 1989 , vol. 54, # 21 p. 5180 - 5182 |
|
~%
52-01-7 |
| Literature: Cella; Tweit Journal of Organic Chemistry, 1959 , vol. 24, p. 1109 |
|
~%
52-01-7 |
| Literature: Wuts, Peter G. M.; Ritter, Allen R. Journal of Organic Chemistry, 1989 , vol. 54, # 21 p. 5180 - 5182 |
|
~%
52-01-7 |
| Literature: Wuts, Peter G. M.; Ritter, Allen R. Journal of Organic Chemistry, 1989 , vol. 54, # 21 p. 5180 - 5182 |
|
~%
52-01-7 |
| Literature: Wuts, Peter G. M.; Ritter, Allen R. Journal of Organic Chemistry, 1989 , vol. 54, # 21 p. 5180 - 5182 |
|
~%
52-01-7 |
| Literature: Wuts, Peter G. M.; Ritter, Allen R. Journal of Organic Chemistry, 1989 , vol. 54, # 21 p. 5180 - 5182 |
|
~%
52-01-7 |
| Literature: Marjani, Katayoun; Khalesi, Maryam; Ashouri, Akram; Jalali, Aazam; Ziyaei-Halimehjani, Azim Synthetic Communications, 2011 , vol. 41, # 3 p. 451 - 458 |
|
~%
52-01-7 |
| Literature: Cella; Tweit Journal of Organic Chemistry, 1959 , vol. 24, p. 1109 |
| Precursor 5 | |
|---|---|
| DownStream 3 | |
| HS Code | 2937290090 |
|---|