120373-24-2
120373-24-2 structure
- Name: Isopropyl unoprostone
- Chemical Name: isopropyl unoprostone
- CAS Number: 120373-24-2
- Molecular Formula: C25H44O5
- Molecular Weight: 424.614
- Catalog: API Hormone and endocrine-regulating drugs Prostaglandins
- Create Date: 2018-02-11 08:00:00
- Modify Date: 2024-01-02 17:53:12
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Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2].
| Name | isopropyl unoprostone |
|---|---|
| Synonyms |
MFCD00886951
Unoprostone Isopropyl Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoate 5-Heptenoic acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl)-, 1-methylethyl ester, (5Z)- Unoprostone Isopropyl Ester Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl]hept-5-enoate (non-preferred name) Isopropyl unoprostone |
| Description | Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
BK channels[1] |
| In Vitro | Isopropyl unoprostone (0.01-1 μM; 24 h) protects against H2O2-induced 661W cell death[2]. Isopropyl unoprostone (0.1-3 μM; 24 h) reduced the morphological change of 661W cells and protects against light-induced cell death[2]. Isopropyl unoprostone (0.001-1 μM; 48 h) suppresses light-induced phagocytotic dysfunction in ARPE-19 cells[2]. Apoptosis Analysis[2] Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then added H2O2) Concentration: 0.01, 0.1 and 1 μM Incubation Time: 24 h Result: Protected against H2O2-induced cell death in a concentration-dependent manner. Apoptosis Analysis[2] Cell Line: 661W (treated with Isopropyl unoprostone for 1 h, then exposed to 2,500 lux of white fluorescent light) Concentration: 0.1, 1 and 3 μM Incubation Time: 24 h Result: Protected against light-induced cell death in a concentration-dependent manner, and the effect was significant at the 1 and 3 μM concentrations; reduced the morphological change (the transition to a rounder shape) which is potentially indicative of a pre-apoptotic stage. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 546.3±45.0 °C at 760 mmHg |
| Molecular Formula | C25H44O5 |
| Molecular Weight | 424.614 |
| Flash Point | 172.2±22.2 °C |
| Exact Mass | 424.318878 |
| PSA | 83.83000 |
| LogP | 4.63 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.492 |
| Storage condition | -20°C Freezer |