Prostaglandins are a group of autologous active substances that are widely present in the body and mediate a variety of physiological functions within the conductor. Prostaglandins in the gastrointestinal tract are mainly prostaglandin E (PGE), prostaglandin F (PGF), and prostacyclin (PGI). The stomach has a lot of prostaglandins, and the gastric mucosa is higher than the submucosa and muscle layer. Prostaglandins protect the gastric mucosa mainly through the following mechanisms: 1. Inhibition of gastric acid secretion prostaglandins can inhibit gastric acid secretion, and the degree of acid suppression is proportional to the dose applied, and inhibits gastric acid secretion after basal and stimulation. 2. Strong cytoprotective cytoprotection refers to the protective effect of prostaglandins on gastric mucosal damage caused by certain harmful substances. Gastric bleeding, ulceration, or necrosis occurs after high doses of aspirin or indomethacin in animals in an animal experiment. Pre or simultaneous administration of prostaglandins prevents the formation of bleeding or ulceration, and this effect is dose dependent. The cytoprotective effect of prostaglandins is mainly through increasing the synthesis and secretion of gastric mucus; stimulating the secretion of bicarbonate from the duodenal epithelium; inhibiting the secretion of histamine, pentagastrin and gastric acid secretion from the digestive tract, and counteracting the vasoconstriction of thromboxane A2. And enhance cell repair capabilities. Prostaglandins used to protect the gastric mucosa mainly include Xi Ke Kui, esprost, leoprost, abaprost, trimoprost, and rosaprost. Among them, only Xike ulcer is officially used in clinical practice. . Xi Ke Kui (Misoprostol) tablets, 200 micrograms per tablet. The recommended dose is 200 micrograms per time, 4 times a day (or before meals and at night before bedtime). The course of treatment is 4 to 8 weeks.
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Amino compound
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Oxy-containing amino compound
Cycloalkylamines, aromatic monoamines, aromatic polyamines and derivatives and salts thereof
Acyclic monoamines, polyamines and their derivatives and salts
Amide compound
Sulfonic acid amino compound
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Alcohols, phenols, phenolic compounds and derivatives
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2-cycloalcohol
Halogenated, sulfonated, nitrated or nitrosated derivatives of alcohols
Extremely halogenated, sulfonated, nitrated or nitrosated derivatives of phenols
Phenol and its halogenated, sulfonated, nitrated or nitrosated derivatives
Acyclic alcohol
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Nitrogen-containing compound
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Nitrile compound
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Organic derivative of hydrazine or hydrazine
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Terpenoid
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Ether compounds and their derivatives
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Ether, ether alcohol
Halogenation, sulfonation, nitration or nitrosation of ethers, ether alcohols, ether phenols
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Aldehyde
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Carboxylic compounds and derivatives
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Cyclic carboxylic acid
Halogenation, sulfonation, nitration or nitrosation of carboxylic acids
Halogenation, sulfonation, nitration or nitration of carboxylic anhydrides
Carboxylic acid halide
Carboxylic esters and their derivatives
Salt of carboxylic acid ester and its derivatives
Acyclic carboxylic acid
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Hydrocarbon compounds and their derivatives
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Aromatic hydrocarbon
Cyclic hydrocarbon
Hydrocarbon sulfonate
Hydrocarbon halide
Hydrocarbon nitrite
Acyclic hydrocarbon
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Ketone compound
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Alkyl ureas and their derivatives and salts
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Inorganic acid ester
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Heterocyclic compound
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Diazo, azo or azo compound
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Organosilicon compound
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Organometallic compound
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Organic palladium
Organic germanium, cobalt, strontium, barium, gallium, germanium, germanium, germanium, germanium, etc.
Organic calcium
Zirconium
Organic potassium
Organic
Organic lithium
Organic
Organic aluminum
Organotin
Organic manganese
Organic sodium
Organic nickel
Organic titanium
Organic iron
Organic copper
Organotin
Organic zinc
Organic
Organic
Organic germanium, mercury, silver, platinum, etc.
Organic germanium, antimony, bismuth, tungsten, antimony, bismuth, lead, vanadium, molybdenum, chromium, antimony, etc.
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Organic sulfur compound
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Organic phosphine compound
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Organometallic salt
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Organic fluorine compound
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Fluorobenzoic acid series
Fluorobenzonitrile series
Fluorobenzaldehyde series
Fluorobenzyl alcohol series
Fluoroanisole series
Fluoroaniline series
Fluorophenylacetic acid series
Fluorophenol series
Fluorobenzoic acid series
Fluoronitrobenzene series
Fluoropyridine series
Potassium fluoroborate series
Fluorobenzyl alcohol series
Fluorotoluene series
Fluorine red series
Fluoroethane series
Fluoropropane series