Inhibition of gastric acid secretion

Proton pump inhibitors: This class of drugs is the latest generation of acid-suppressing drugs currently in clinical use, and its acid-suppressing effect is strong and long-lasting. The proton pump acts on the last part of the gastric acid secretion process, and after being absorbed into the blood, it reaches the secretory tubules of the gastric parietal cells, transforms into active substances in an acidic environment, acts on the H+-K+-ATPase and inactivates it. The hydrogen ions in the parietal cells can not be transferred to the gastric cavity to reduce the gastric acid secretion, thereby increasing the pH value in the gastric juice, thereby achieving acid suppression. The main clinical drugs currently used are: omeprazole, lansoprazole, pantoprazole and rabeprazole. The chemical structures of these drugs are similar, all have a certain lipophilicity and easily penetrate the cell wall. This type of drug is very unstable in an acidic environment and is easily destroyed by gastric acid, so it should not be taken apart or chewed after oral administration. These drugs are well tolerated and relatively low in adverse reactions. Common adverse reactions are mainly gastrointestinal reactions (abdominal pain, bloating, nausea, vomiting, etc.), psychiatric symptoms (anxiety and depression, headache, etc.) and minor liver damage. Individual patients may develop an allergic reaction such as a rash. The incidence of various adverse reactions mentioned above is not high and relatively mild, and usually disappears on its own during the process of continued use.