Piperazines are a class of compounds containing a piperazine structure in the structure of a compound. These compounds are an important class of pharmaceutical intermediates, mainly used in the production of the anthelmintic drugs piperazine phosphate, piperazine citrate and fluphene. Nai Jing, Qiang Ding, Li Fuping. It is also used to produce surfactants such as wetting agents, emulsifiers and dispersants, as well as plastic processing aids and rubber auxiliaries such as antioxidants, preservatives and stabilizers. Piperazine is also known as hexahydropyrazine or diethylenediamine. The precipitated from ethanol is white orthorhombic leaf-like crystal with mild amine odor, salty taste and hygroscopicity. The relative density is 0.876, the melting point is 106.6 ° C, and the boiling point is 146 ° C. Soluble in water and glycerin, slightly soluble in ethanol, insoluble in ether. It has strong alkalinity, and the pH of the 10% aqueous solution is 10.8 to 11.8. It absorbs carbon dioxide from the air. Irritating to eyes and skin. With a typical secondary amine reaction. It can be obtained by reacting ethylenediamine with 1,2-dichloroethane or by dimerization of aminoethanol at high temperature. Its inorganic acids and organic acid salts are used as an anthelmintic drug for humans and animals. They are effective drugs for repelling aphids and aphids, and are also used for organic synthesis. Piperazine is also known as "driver". It has a strong effect on aphids and mites. It can make the aphid muscles loose and paralyzed, so the worm can not be excreted by the peristaltic movement. There is no excitement before the parasites are paralyzed, so it is safer. It can be used for incomplete intestinal obstruction caused by aphids and early biliary ascariasis, and can also be used in patients with ulcer disease. The general dose cure rate can reach 70% to 80%, and the cure rate can be improved by continuous medication for 2 days. For the treatment of scrub typhus, it takes 7 to 10 days for continuous medication. The toxicity of this drug is very low, and the treatment amount is occasionally nausea, vomiting and urticaria.
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Amino compound
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Oxy-containing amino compound
Cycloalkylamines, aromatic monoamines, aromatic polyamines and derivatives and salts thereof
Acyclic monoamines, polyamines and their derivatives and salts
Amide compound
Sulfonic acid amino compound
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Alcohols, phenols, phenolic compounds and derivatives
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2-cycloalcohol
Halogenated, sulfonated, nitrated or nitrosated derivatives of alcohols
Extremely halogenated, sulfonated, nitrated or nitrosated derivatives of phenols
Phenol and its halogenated, sulfonated, nitrated or nitrosated derivatives
Acyclic alcohol
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Nitrogen-containing compound
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Nitrile compound
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Organic derivative of hydrazine or hydrazine
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Terpenoid
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Ether compounds and their derivatives
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Ether, ether alcohol
Halogenation, sulfonation, nitration or nitrosation of ethers, ether alcohols, ether phenols
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Aldehyde
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Carboxylic compounds and derivatives
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Cyclic carboxylic acid
Halogenation, sulfonation, nitration or nitrosation of carboxylic acids
Halogenation, sulfonation, nitration or nitration of carboxylic anhydrides
Carboxylic acid halide
Carboxylic esters and their derivatives
Salt of carboxylic acid ester and its derivatives
Acyclic carboxylic acid
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Hydrocarbon compounds and their derivatives
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Aromatic hydrocarbon
Cyclic hydrocarbon
Hydrocarbon sulfonate
Hydrocarbon halide
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Acyclic hydrocarbon
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Ketone compound
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Alkyl ureas and their derivatives and salts
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Inorganic acid ester
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Heterocyclic compound
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Diazo, azo or azo compound
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Organosilicon compound
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Organometallic compound
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Organic palladium
Organic germanium, cobalt, strontium, barium, gallium, germanium, germanium, germanium, germanium, etc.
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Organotin
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Organotin
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Organic
Organic germanium, mercury, silver, platinum, etc.
Organic germanium, antimony, bismuth, tungsten, antimony, bismuth, lead, vanadium, molybdenum, chromium, antimony, etc.
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Organic sulfur compound
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Organic phosphine compound
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Organometallic salt
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Organic fluorine compound
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Fluorobenzoic acid series
Fluorobenzonitrile series
Fluorobenzaldehyde series
Fluorobenzyl alcohol series
Fluoroanisole series
Fluoroaniline series
Fluorophenylacetic acid series
Fluorophenol series
Fluorobenzoic acid series
Fluoronitrobenzene series
Fluoropyridine series
Potassium fluoroborate series
Fluorobenzyl alcohol series
Fluorotoluene series
Fluorine red series
Fluoroethane series
Fluoropropane series