Anti-migraine drug

Migraine is the most common type of vascular headache. It is often a side pain, sometimes accompanied by nausea, vomiting, fear of sound, and photophobia. There may be signs of visual impairment before pain. The pathogenesis of migraine is complicated. It has not been fully elucidated. There are signs and symptoms of the nervous system in the aura, and the blood flow in the brain is sharply reduced. Brain tissue ischemia may be associated with the release of 5-HT from platelets. Typical migraine is often localized. Following the decrease of ductile blood flow, the blood flow in the brain and extracranial blood vessels increased, the amplitude of vascular pulse pulse increased, and the intracranial artery increased more obviously. The expansion of the heart lumen and the opening of the anastomotic branch of the artery and vein are one of the mechanisms of headache attack. Metabolic disorders such as prostaglandins, neurokinins, acetylcholine, histamine, and endocrine dysfunction are also associated with the onset of migraine. In particular, 5-HT metabolism is closely related to the pathogenesis of this disease. The commonly used drugs for this purpose are 5-HT antagonists, such as ergotamine, mesalamine and sumatriptan; in addition, antihistamines such as phenylthiazine, cyproheptadine, etc., and calcium antagonists, Such as nimodipine and adrenal receptor blockers, such as 吲哚olol and so on.