The isoquinoline is a heterocyclic compound containing a benzene ring and a pyridine ring, and the isoquinoline is an isomer of quinoline, that is, a product in which the CH group at the β position of the naphthalene molecule is substituted with an N atom. Colorless to pale yellow liquid. Or flaky crystals, similar to fennel oil and benzaldehyde to stimulate the odor, water absorption, and its alkalinity is stronger than quinoline. It is chemically active and can undergo nucleophilic, electrophilic, oxidative, and reduction reactions. Many alkaloids such as papaverine, berberine, and morphine base contain the basic structures of isoquinoline and hydrogenated isoquinoline. Uses: isoquinoline can be used as a solvent for polyimine film; raw materials for organic conductors, dyes, photographic pigments, insecticides, alkaloids, pharmaceuticals and fungicides, rubber vulcanization accelerators; pyridine carboxylic acid after oxidation; Quinoline hydrochloride is a chemical reagent for the determination of zinc, cadmium, cobalt, copper, etc.; preparation of isoquinoline derivatives and the like. System of law: (1) The Bischler method proposed in 1893. The acylate of β-phenylethylamine is used as a raw material, and under the action of the dehydrating agent phosphorus pentoxide (or ZnCl2, POCl3, etc.), dehydration, condensation and ring closure to form 3,4-dihydroisoquinoline, and then in palladium Under the catalysis, oxidative dehydrogenation at 190 ° C can produce isoquinoline. (2) Rearrangement of cinnamaldehyde oxime. Beckmann rearrangement is carried out under the action of phosphorus pentoxide (or sulfuric acid, polyphosphoric acid). Then dehydration closed loop, can be made.
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Amino compound
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Oxy-containing amino compound
Cycloalkylamines, aromatic monoamines, aromatic polyamines and derivatives and salts thereof
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Amide compound
Sulfonic acid amino compound
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Alcohols, phenols, phenolic compounds and derivatives
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2-cycloalcohol
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Nitrogen-containing compound
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Nitrile compound
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Organic derivative of hydrazine or hydrazine
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Terpenoid
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Ether, ether alcohol
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Aldehyde
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Cyclic carboxylic acid
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Aromatic hydrocarbon
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Inorganic acid ester
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Organometallic salt
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Fluorobenzoic acid series
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Fluoropropane series