Name | tafamidis |
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Synonyms |
6-Benzoxazolecarboxylic acid, 2-(3,5-dichlorophenyl)-
Tafamidis 8FG9H9D31J 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid UNII-8FG9H9D31J FX-1006 3MI |
Description | Tafamidis(Fx1006A) is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.Target: OthersTafamidis is a drug for the amelioration of transthyretin-related hereditary amyloidosis.Tafamidis functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein. Tafamidis binds selectively and with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants, are also stabilized by tafamidis binding. The crystal structure of tafamidis-bound TTR suggests that binding stabilizes the weaker dimer-dimer interface against dissociation, the rate-limiting step of amyloidogenesis [1]. |
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Related Catalog | |
References |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 486.7±40.0 °C at 760 mmHg |
Molecular Formula | C14H7Cl2NO3 |
Molecular Weight | 308.116 |
Flash Point | 248.1±27.3 °C |
Exact Mass | 306.980286 |
PSA | 63.33000 |
LogP | 5.29 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.677 |
Storage condition | 2-8℃ |
~% 594839-88-0 |
Literature: Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122 |
~% 594839-88-0 |
Literature: Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122 |
~% 594839-88-0 |
Literature: Chemistry - A European Journal, , vol. 17, # 36 p. 10113 - 10122 |
~% 594839-88-0 |
Literature: WO2013/168014 A1, ; |
Precursor 4 | |
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DownStream 0 |