1128165-88-7

1128165-88-7 structure

Name: Dynole 34-2
Chemical Name: (2E)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-N-octy lacrylamide
CAS Number: 1128165-88-7
Molecular Formula: C₂₅H₃₆N₄O
Molecular Weight: 408.58000
Catalog: Signaling Pathways Cytoskeleton Dynamin
Create Date: 2016-12-18 10:23:35
Modify Date: 2024-01-09 20:09:59
Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].

Name	(2E)-2-Cyano-3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-N-octy lacrylamide
Synonyms	3-Pyridinecarboxylicacid,2-cyano 2-cyanonicotinic acid Pyridin-2-cyano-3-carbonsaeure 2-cyano-3-pyridinecarboxylic acid

Description	Dynole 34-2 is a dynamin GTPase inhibitor (IC50s=6.9 and 14.2 µM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage[1]. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Dynamin
References	[1]. Chircop M, et al. Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells. Mol Cancer Ther. 2011 Sep;10(9):1553-62. [2]. Hill TA, et al. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles. J Med Chem. 2009 Jun 25;52(12):3762-73.