168682-53-9
168682-53-9 structure
- Name: ezatiostat
- Chemical Name: ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate
- CAS Number: 168682-53-9
- Molecular Formula: C27H35N3O6S
- Molecular Weight: 529.648
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
- Create Date: 2017-10-06 06:56:54
- Modify Date: 2024-01-11 15:22:08
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Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).
| Name | ethyl (2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate |
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| Synonyms |
Ethyl (2S)-2-amino-5-{[(2R)-3-(benzylsulfanyl)-1-{[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino}-1-oxo-2-propanyl]amino}-5-oxopentanoate
Ter-199 TLK-199 ezatiostat UNII-057D10I8S8 Telintra Terrapin 199 |
| Description | Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1). |
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| Related Catalog | |
| In Vitro | Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 749.7±60.0 °C at 760 mmHg |
| Molecular Formula | C27H35N3O6S |
| Molecular Weight | 529.648 |
| Flash Point | 407.2±32.9 °C |
| Exact Mass | 529.224670 |
| PSA | 169.10000 |
| LogP | 4.27 |
| Appearance | white solid |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.569 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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