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23111-00-4

23111-00-4 structure
23111-00-4 structure
  • Name: Nicotinamide riboside chloride
  • Chemical Name: Pyridinium, 3-​(aminocarbonyl)​-​1-​β-​D-​ribofuranosyl-​, chloride (1:1)
  • CAS Number: 23111-00-4
  • Molecular Formula: C11H15ClN2O5
  • Molecular Weight: 290.70000
  • Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
  • Create Date: 2017-11-03 08:23:33
  • Modify Date: 2024-01-04 10:05:13
  • Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements[1].

Name Pyridinium, 3-​(aminocarbonyl)​-​1-​β-​D-​ribofuranosyl-​, chloride (1:1)
Description Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements[1].
Related Catalog
Target

SIRT1

SIRT3

In Vitro Nicotinamide riboside chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2.
In Vivo Chronic Nicotinamide riboside chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner.
References

[1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47.

Molecular Formula C11H15ClN2O5
Molecular Weight 290.70000
Exact Mass 290.06700
PSA 116.89000
Storage condition 2-8℃
Precursor  0

DownStream  1