Name | Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl-, chloride (1:1) |
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Description | Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride which is a nicotinamide adenine dinucleotide (NAD[+]) precursor vitamin. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements[1]. |
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Related Catalog | |
Target |
SIRT1 SIRT3 |
In Vitro | Nicotinamide riboside chloride (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2. |
In Vivo | Chronic Nicotinamide riboside chloride (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner. |
References |
Molecular Formula | C11H15ClN2O5 |
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Molecular Weight | 290.70000 |
Exact Mass | 290.06700 |
PSA | 116.89000 |
Storage condition | 2-8℃ |
Precursor 0 | |
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DownStream 1 | |